The influence of long-term CPAP therapy on metabolic variables in obstructive sleep apnea patients

W. Kuczynski (Lodz, Poland), A. Stolarz (Lodz, Poland), P. Bialasiewicz (Lodz, Poland)

Source: International Congress 2018 – Cardiovascular and metabolic consequences of sleep-disordered breathing

Session: Cardiovascular and metabolic consequences of sleep-disordered breathing
Session type: Thematic Poster
Number: 4334

Disease area: Sleep and breathing disorders

Abstract

Introduction: Obstructive sleep apnea (OSA) is characterized by repeated interruption of ventilation during sleep due to pharyngeal airway closure. Continuous positive airway pressure (CPAP) is the most effective therapy in moderate and severe OSA. The influence of CPAP on metabolism is not fully appraised.

Purpose: This study was designed to assess the influence of long-term CPAP therapy on blood glucose concentration, insulin resistance, blood lipids in one-year observation.

Methods: All patients underwent overnight polysomnography. 53 patients were classified due to apnea-hypopnea index (AHI) into 3 groups: mild, moderate and severe OSA. We excluded from the study patients with any known thyroid diseases. Blood samples were collected before introducing CPAP and after one year of therapy.

results: 22 patients had AHI(5-15) average glucose was 105.6 mg/dl(SD 13.7), cholesterol 173.3(SD 44.9), triglycerides 123.7(SD 75.4), LDL 106.0(SD43.1); after one year glucose was 114.1(SD 21.9 p=0.02), cholesterol 205.7(SD 59.0 p=0.003); triglycerides 162.6(SD 97.6 p=0.001), 129.5(SD 54.6 p=0.02). 31 patients had AHI(>15) and they started CPAP therapy. Serum results before and after 12 months were: glucose 116.9mg/dl(SD 25.9), cholesterol 192.0mg/dl(SD 38.1), triglycerides 145.2mg/dl(SD 81.3), LDL 120.6mg/dl(SD 34.8), after one year of CPAP glucose 114.5mg/dl(SD34.5 p=0.5), cholesterol 185.4mg/dl(SD 36.3 p=0.29), triglycerides 157.9md/dl(SD 110.3 p=0.46), LDL 111.2mg/dl(SD 31.3 p=0.13).

Conclusions: Patients without CPAP therapy during 12 months had significantly higher glucose, cholesterol, triglycerides, LDL (p<0.05) compared to CPAP patients on CPAP where no changes were observed.

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W. Kuczynski (Lodz, Poland), A. Stolarz (Lodz, Poland), P. Bialasiewicz (Lodz, Poland). The influence of long-term CPAP therapy on metabolic variables in obstructive sleep apnea patients. 4334

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