Hypoxia effect on the hepatic profile, glucose metabolism and cardiovascular risk.

B. Aldave Orzaiz (Madrid, Spain), P. Landete Rodriguez (Madrid, Spain), C. Acosta Gutierrez (Madrid, Spain), M. Hernandez Olivo (Madrid, Spain), M. Gonzalez GonzáLez (Madrid, Spain), J. Muñoz Olmedo (Madrid, Spain), A. Friera Reyes (Madrid, Spain), A. Sanchez Azofra (Madrid, Spain), E. Zamora Garcia (Madrid, Spain), A. Gonzalez Rodriguez (Madrid, Spain), J. Soriano (Madrid, Spain), C. Garcia Monzon (Madrid, Spain), J. Ancochea Bermudez (Madrid, Spain)

Source: International Congress 2018 – Cardiovascular and metabolic consequences of sleep-disordered breathing

Session: Cardiovascular and metabolic consequences of sleep-disordered breathing
Session type: Thematic Poster
Number: 4329

Disease area: Sleep and breathing disorders

Abstract

Introduction

We analyse the hypoxia effect on the hepatic profile, glucose metabolism and cardiovascular risk in patients with COPD (Chronic Obstructive Pulmonary Disease), OSA (Obstructive Sleep Apnea) or both.

Material and methods

Prospective study with control patients, COPD, OSA or overlap. A blood analysis(inflammatory and metabolic profile) was made. Anthropometric measures and cardiovascular risk factors were collected. We compared demographic and clinical characteristics.

Results

223 patients: COPD 17%, OSA 51%, Overlap 17%, control 14%. 54% overlap, 49% OSA, 34% COPD and 22% control (p<0.001) have steatohepatitis measured by OW-liver. Figure: percentages of patients with dyslipidemia (DL), atrial fibrillation (AF), congestive heart failure (CHF) and acute myocardial infarction (AMI). Table: average ±standard deviation of variables related to metabolic and inflammatory profile. There is a trend towards greater insulinaemia 17’04±13’22 (p=0’078) and HOMA 5’08±8’14 (p=0’277) in OSA patients.

Conclusions

Patients with intermittent hypoxia have more AMI, CHF, AF and DL; as well as worse metabolic and inflammatory profile than patients with continuous hypoxia.

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B. Aldave Orzaiz (Madrid, Spain), P. Landete Rodriguez (Madrid, Spain), C. Acosta Gutierrez (Madrid, Spain), M. Hernandez Olivo (Madrid, Spain), M. Gonzalez GonzáLez (Madrid, Spain), J. Muñoz Olmedo (Madrid, Spain), A. Friera Reyes (Madrid, Spain), A. Sanchez Azofra (Madrid, Spain), E. Zamora Garcia (Madrid, Spain), A. Gonzalez Rodriguez (Madrid, Spain), J. Soriano (Madrid, Spain), C. Garcia Monzon (Madrid, Spain), J. Ancochea Bermudez (Madrid, Spain). Hypoxia effect on the hepatic profile, glucose metabolism and cardiovascular risk.. 4329

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