The impact of obstructive sleep apnea in case of acute coronary syndrome
G. Calcaianu (Mulhouse, France), E. Virot (Mulhouse, France), D. Bresson (Mulhouse, France), M. Calcaianu (Mulhouse, France), C. Iamandi (Mulhouse, France), D. Debieuvre (Mulhouse, France)
Source: International Congress 2018 – Cardiovascular and metabolic consequences of sleep-disordered breathing
Disease area: Sleep and breathing disorders
Abstract Background: Obstructive sleep apnea (OSA) is a well-known cardio-vascular risk factor. However, there is no currently prominent screening strategy for its diagnosis in patients with acute coronary syndrome (ACS). The aim of this study was to establish the incidence of the OSA and its impact in the case of ACS.
Methods: Between January 1st to June 30th, we prospectively evaluated for OSA 53 patients with ACS (first myocardial infarction). Each patient underwent a polysomnography, 8 weeks after the ACS.
Results: mean age 59.5±9.6 years, 81.1% male, BMI at 28.5±4.2 Kg/m², neck circumference 42.5±12.6 cm, waist perimeter 102.5±16.5 cm. ST elevation myocardial infarction (STEMI) was present in 66% of cases. The majority of patients (73.6%) had a moderate to severe OSA (apnea hypopnea index (AHI) = 15/h with arousal index = 10/h), without a significant sleepiness (mean Epworth score at 6.6±3.9).
The patients with a higher ratio of apnea events (apnea index/apnea-hypopnea index > 37% vs. < 37%) had a higher level of Troponin (69±63.4 vs. 24.8±36.6 ng/mL, p=0.021), a higher NTproBNP level (2580.6±3944.3 vs. 429.2±560 pg/ml, p=0.001) and lower left ventricle ejection fraction (LVEF) (51.9±11.9% vs. 60.8±5.4%, p=0.007).
Conclusions: This study showed a high incidence of OSA in patients with ACS. Also, we observed that the patients with more than 37% apnea events showed worsen cardiac status (higher Troponin and NTproBNP level and lower LVEF).
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G. Calcaianu (Mulhouse, France), E. Virot (Mulhouse, France), D. Bresson (Mulhouse, France), M. Calcaianu (Mulhouse, France), C. Iamandi (Mulhouse, France), D. Debieuvre (Mulhouse, France). The impact of obstructive sleep apnea in case of acute coronary syndrome. 4315
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