Dynamic hyperinflation predicts impaired daily life activity in asthma
A. van der Meer (Leeuwarden, Netherlands), K. De Jong (Leeuwarden, Netherlands), E. Bel (Amsterdam, Netherlands), A. Ten Brinke (Leeuwarden, Netherlands)
Source: International Congress 2018 – Clinical markers of asthma
Session: Clinical markers of asthma
Session type: Thematic Poster
Number: 4001
Disease area: Airway diseases
Abstract Introduction: We previously showed a high prevalence of dynamic hyperinflation in asthma, but it’s impact on overall health, activities of daily life and perceived well-being is unknown.
Aim: To investigate the relationship between dynamic hyperinflation and the scores of a set of specific and general respiratory health questionnaires.
Method: 77 adult non-smoking outpatients with stable asthma receiving GINA step 4-5 treatment were consecutively recruited, and completed the following questionnaires: ACQ (Asthma Control Questionnaire), CCQ (COPD Control Questionnaire), SGRQ (St. George’s Respiratory Questionnaire), LCADL (London Chest Activity of Daily Living scale), SOBDA (Shortness of Breath with Daily Activities). Dynamic hyperinflation was defined as =10% reduction in inspiratory capacity induced by standardized metronome-paced tachypnea. Associations between the level of dynamic hyperinflation and questionnaire scores were assessed with univariate analyses and adjusted for asthma severity (ACQ, FEV1, inhaled corticosteroid dose).
Results: 62 patients (58±14 yr, 42% females) showed dynamic hyperinflation. Higher levels of dynamic hyperinflation were related to poorer scores on all questionnaires (r=0.228-0.385, p<0.05). After adjustment for asthma severity, dynamic hyperinflation remained associated with poorer scores on LCADL (p=0.03) and SOBDA (p=0.03), but not with the other questionnaires.
Conclusion: Dynamic hyperinflation is associated with poorer overall health, less well-being and impaired activities of daily life, independent of asthma severity. Because of its major impact on everyday life activities dynamic hyperinflation is an important target for treatment in asthma patients.
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A. van der Meer (Leeuwarden, Netherlands), K. De Jong (Leeuwarden, Netherlands), E. Bel (Amsterdam, Netherlands), A. Ten Brinke (Leeuwarden, Netherlands). Dynamic hyperinflation predicts impaired daily life activity in asthma. 4001
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