Patterns of sensitization to furry animal allergen components in adult asthma and indicators of severity
B. Nwaru (Gothenburg, Sweden), S. Suzuki (Tokyo, Japan), L. Ekerljung (Gothenburg, Sweden), S. Sjölander (Uppsala, Sweden), R. Mincheva (Gothenburg, Sweden), E. Rönmark (Gothenburg, Sweden), E. Rönmark (Umeå, Sweden), M. Borres (Uppsala, Sweden), B. Lundbäck (Gothenburg, Sweden), J. Lötvall (Gothenburg, Sweden)
Source: International Congress 2018 – Clinical markers of asthma
Session: Clinical markers of asthma
Session type: Thematic Poster
Number: 3999
Disease area: Airway diseases
Abstract BACKGROUND: Whilst the role of allergen component sensitization in asthma has been investigated in children, studies in adults are lacking.
AIM: To study the relationship between patterns of sensitization to furry animal allergen components and asthma, concomitant asthma/allergic rhinitis, and indicators of asthma severity in a population-representative adult sample.
METHODS: From the West Sweden Asthma Study, 2006 were clinically phenotyped, of which 1872 had Phadiatop analyzed. Those with IgE>0.35 kUA/L were then analyzed for specific cat (Fel d 1, 2, & 4), dog (Can f 1, 2, 3, & 5), and horse (Equ c 1) allergen components. Sensitization patterns were defined as mono-, double-, and poly-sensitization (i.e. >2 components). Outcomes were current asthma, current allergic rhinitis, concomitant asthma/rhinitis, and indicators of asthma severity.
RESULTS: Mono-, double-, and poly-sensitization to furry animal components were each associated with a substantial increased risk of asthma, allergic rhinitis, concomitant asthma/rhinitis, and ACT well-controlled asthma. Poly-sensitization was further associated with increased FeNo (ß 0.43, 95%CI 0.18 to 0.68) and eosinophil (ß 0.26, 95%CI 0.02 to 0.50) levels, and lower PD20 methacoline values (ß -0.57, 95%CI -0.99 to -0.15). Sensitization patterns were not associated with asthma exacerbations, FEV1 values, emergency visits or oral steroid use, and neutrophil levels.
CONCLUSION: Patterns of sensitization to furry animal allergen components are a good predictor of clinical outcomes and indicators of asthma severity in adults, but only poly-sensitization had impact on eosinophilic inflammatory markers of severity.
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B. Nwaru (Gothenburg, Sweden), S. Suzuki (Tokyo, Japan), L. Ekerljung (Gothenburg, Sweden), S. Sjölander (Uppsala, Sweden), R. Mincheva (Gothenburg, Sweden), E. Rönmark (Gothenburg, Sweden), E. Rönmark (Umeå, Sweden), M. Borres (Uppsala, Sweden), B. Lundbäck (Gothenburg, Sweden), J. Lötvall (Gothenburg, Sweden). Patterns of sensitization to furry animal allergen components in adult asthma and indicators of severity. 3999
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