Correlation between reduced forced expiratory flow between 25% and 75% (FEF 25-75%) and a positive methacholine challenge test (MCT) in adults with non-obstructive baseline spirometry.
I. Shafiq (Abu Dhabi, United Arab Emirates), A. Wahla (Abu Dhabi, United Arab Emirates), M. Uzbeck (Abu Dhabi, United Arab Emirates), N. Parappurath (Abu Dhabi, United Arab Emirates), Z. Zoumot (Abu Dhabi, United Arab Emirates)
Source: International Congress 2018 – Clinical markers of asthma
Session: Clinical markers of asthma
Session type: Thematic Poster
Number: 3987
Disease area: Airway diseases
Abstract Introduction
Reduced FEF 25-75% is thought to be a marker of small airway obstruction and is reduced in children with asthma. Its significance in adults with a non-obstructive spirogram is unclear. This study aims to clarify whether in adults with a non-obstructive spirogram (Normal FEV1 & FEV1/FVC) a reduced FEF25-75% is associated with a positive MCT.
Methods
We collected retrospective data of all the patients who had a methacholine challenge test done between April 2014 and February 2018 at the pulmonary clinic in Cleveland clinic Abu Dhabi.
Results
We reviewed the data for 221 patients out of which 84 (69%) had a positive MCT. Baseline characteristics in two groups were similar except that patients with positive MCT were significantly younger (32.56 vs 38.71 years, p 0.0009). MCT positive patients had significantly lower FEV1/FVC (82.19% vs 83.92%, p 0.0471), FEF 25-75% (3.12 vs 3.42, p 0.0212) and %predicted FEF 25-75% (88% vs 103% p 0.000002). We found a week negative correlation between % predicted FEF 25-75% and positive MCT (r -0.31). Sensitivity & specificity for FEF25-75% of <80% predicted in predicting positive MCT were 38% and 84% respectively.
Conclusion:
In adults with non-obstructive spirometry a reduced % predicted FEF25-75% may be associated with +ive MCT signifying airway hyper-reactivity/Asthma.
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I. Shafiq (Abu Dhabi, United Arab Emirates), A. Wahla (Abu Dhabi, United Arab Emirates), M. Uzbeck (Abu Dhabi, United Arab Emirates), N. Parappurath (Abu Dhabi, United Arab Emirates), Z. Zoumot (Abu Dhabi, United Arab Emirates). Correlation between reduced forced expiratory flow between 25% and 75% (FEF 25-75%) and a positive methacholine challenge test (MCT) in adults with non-obstructive baseline spirometry.. 3987
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