Short 12-month regimen with intravenouse linezolid for MDR-TB: treatment outcomes and first follow up results.
N. Lytvynenko (Kyiv, Ukraine), H. Varytska (Kyiv, Ukraine), M. Pogrebna (Kyiv, Ukraine), Y. Senko (Kyiv, Ukraine), O. Chobotar (Kyiv, Ukraine)
Source: International Congress 2018 – New developments in tuberculosis
Session: New developments in tuberculosis
Session type: Oral Presentation
Number: 1961
Disease area: Respiratory infections
Abstract The aim: improve the treatment outcomes among MDR- TB patients using the short 12-month regimen. In the prospective observational "case-control" study were included 86 patients with new MDR-TB cases and with susceptibility to second line ADTs. Patients of the first group (n=43) received following short 12-month MDR-TB regimen: during intensive phase at least 6 ATDs (20 weeks): linezolid (0.6 g), levofloxacin (1.0 g) - intravenus, kanamycine (1.0 g) – intramusculary and pyrazinamide, prothionamide, cycloserine – in therapeutic doses respectively; continuation phase -at least 5 ATDs (without kanamycine) during 28 weeks. The patients of the second group (n=43) received conventional 20-month regimens (without linezolid).
Results. Among patients, who were treated by short MDR-TB regimen, comparing to the conventional treatment regimen the success rate increased from 30 (69,7%) to 41 (95,4 %)). The adverse events registration wasn`t significantly higher -in 69,8 % vs. 58,2 %, respectively. Among success rate patients, relapses during 12 month follow up period were only in 3 (7,0 %) patients after end of conventional 20-month regimen. So, failure of treatment had 21 % of patients with conventional 20-month regimen, in comparison 2,3 % patients with 12-month short regimen with linezolid.
Conclusions. Administration of short 12-month regimen for MDR - TB patients improved the successful treatment outcomes in patients with MDR-TB to 95.4% in comparison with the use of conventional regimen. Relapses were only in 3 (7,0 %) patients after conventional 20-month regimen.
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N. Lytvynenko (Kyiv, Ukraine), H. Varytska (Kyiv, Ukraine), M. Pogrebna (Kyiv, Ukraine), Y. Senko (Kyiv, Ukraine), O. Chobotar (Kyiv, Ukraine). Short 12-month regimen with intravenouse linezolid for MDR-TB: treatment outcomes and first follow up results.. 1961
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