Management of tuberculosis in the European Union: a multicentre audit
S. Rosales-Klintz (Stockholm, Sweden), L. D’Ambrosio (Tradate, Italy), R. Centis (Tradate, Italy), R. Verduin (Oegstgeest, Netherlands), M. Amicosante (Rome, Italy), A. Correia (Porto, Portugal), A. Cirule (Riga, Latvia), R. Duarte (Porto, Portugal), B. Gadzheva (Sofia, Bulgaria), G. Gualano (Rome, Italy), H. Kunst (London, United Kingdom), F. Palmieri (Rome, Italy), V. Riekstina (Riga, Latvia), D. Stefanova (Sofia, Bulgaria), S. Tiberi (London, United Kingdom), G. Sotgiu (Sassari, Italy), G. Migliori (Tradate, Italy), M. Van Der Werf (Stockholm, Sweden)
Source: International Congress 2018 – New developments in tuberculosis
Session: New developments in tuberculosis
Session type: Oral Presentation
Number: 1958
Disease area: Respiratory infections
Abstract Introduction: In 2010, a clinical audit on tuberculosis (TB) management in the European Union and European Economic Area (EU/EEA) identified important gaps between international standards of care and the management of TB patients, particularly for those with multidrug- or extensively drug resistant tuberculosis (MDR/XDR-TB). The results informed the development of the European Union Standards for TB Care (ESTC).
Objective: We conducted a new audit aiming at assessing if TB management, including infection control measures, in EU/EEA clinical care centres was consistent with the ESTC.
Methods: TB reference hospitals in five EU/EEA countries were purposely selected. In each hospital a maximum of 40 medical records of consecutive confirmed TB cases, diagnosed between 2012 and 2014, were reviewed. Ethical approval was obtained if required by the local legislation.
Results: Data from 122 patients with XDR-TB (n= 11), pre-XDR-TB (n= 29) MDR-TB (n= 49), and drug-susceptible TB (n= 33) showed that TB diagnosis and treatment were according to the ESTC. Treatment outcomes were duly registered and hospitals reached the target for treatment success (75-100%) for patients with drug-resistant TB. All TB patients were offered, and subsequently accepted, HIV testing and counselling. However, antiretroviral treatment was not immediately offered to all TB patients co-infected with HIV. Infection control procedures were properly implemented. Therapeutic drug monitoring and routine genetic typing of TB strains, although not considered a standard in the ESTC, were used in some EU/EEA settings.
Conclusions: Overall, selected EU/EEA reference centres reported good adherence to the ESTC.
Rating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
S. Rosales-Klintz (Stockholm, Sweden), L. D’Ambrosio (Tradate, Italy), R. Centis (Tradate, Italy), R. Verduin (Oegstgeest, Netherlands), M. Amicosante (Rome, Italy), A. Correia (Porto, Portugal), A. Cirule (Riga, Latvia), R. Duarte (Porto, Portugal), B. Gadzheva (Sofia, Bulgaria), G. Gualano (Rome, Italy), H. Kunst (London, United Kingdom), F. Palmieri (Rome, Italy), V. Riekstina (Riga, Latvia), D. Stefanova (Sofia, Bulgaria), S. Tiberi (London, United Kingdom), G. Sotgiu (Sassari, Italy), G. Migliori (Tradate, Italy), M. Van Der Werf (Stockholm, Sweden). Management of tuberculosis in the European Union: a multicentre audit. 1958
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you:
Performance of immune-based and microbiological tests in children with tuberculosis meningitis in Europe: a multicentre Paediatric Tuberculosis Network European Trials Group (ptbnet) study Source: Eur Respir J, 56 (1) 1902004; 10.1183/13993003.02004-2019 Year: 2020
Tuberculosis in the European Union and European Economic Area: a survey of national tuberculosis programmes Source: Eur Respir J, 52 (6) 1801449; 10.1183/13993003.01449-2018 Year: 2018
The EMBARC European Bronchiectasis Registry: protocol for an international observational study Source: ERJ Open Res 2016 Year: 2016
TB and MDR/XDR-TB in European Union and European Economic Area countries: managed or mismanaged? Source: Eur Respir J 2012; 39: 619-625 Year: 2012
Severe Paediatric Asthma Collaborative in Europe (SPACE): protocol for a European registry Source: Breathe, 14 (2) 93; 10.1183/20734735.002018 Year: 2018
The Tuberculosis Network European Trials group (TBnet) ERS Clinical Research Collaboration: addressing drug-resistant tuberculosis through European cooperation Source: Eur Respir J, 53 (1) 1802089; 10.1183/13993003.02089-2018 Year: 2019
The Tuberculosis Network European Trials Group (TBNET): new directions in the management of tuberculosis Source: Breathe, 13 (3) e65; 10.1183/20734735.005517 Year: 2017
Call for urgent actions to ensure access to early diagnosis and care of tuberculosis among refugees: Statement of the European Respiratory Society and the European Region of the International Union Against Tuberculosis and Lung Disease Source: Eur Respir J 2016; 47:1345-1347 Year: 2016
European Union Standards for Tuberculosis Care Source: Eur Respir J 2012; 39: 807-819 Year: 2012
The European Union standards for tuberculosis care: do they need an update? Source: Eur Respir J 2014; 43: 933-942 Year: 2014
ERS/ECDC updated European Union standards of tuberculosis care Source: International Congress 2018 – Important changes in the management of tuberculosis Year: 2018
European framework for tuberculosis control and elimination in countries with a low incidence: Recommendations of the World Health Organization (WHO), International Union Against Tuberculosis and Lung Disease (IUATLD) and Royal Netherlands Tuberculosis Source: Eur Respir J 2002; 19: 765-775 Year: 2002
Fighting tuberculosis in the EU/EEA: towards the new European Union standards on tuberculosis care Source: Eur Respir J 2016; 48: 1278-1281 Year: 2016
Research priorities in bronchiectasis: A consensus from the European multicentre bronchiectasis audit and research collaboration (EMBARC) study group Source: International Congress 2015 – Adult bronchiectasis: risk factors and future perspectives Year: 2015
Drug-resistant tuberculosis in the European Union and European economic area Source: International Congress 2015 – The emergence of drug-resistant tuberculosis in Europe: no cure possible? Year: 2015
Drug resistance among tuberculosis cases in the European Union and European Economic Area, 2007 to 2012 Source: International Congress 2014 – Tuberculosis: public health and primary prevention Year: 2014
Social determinants of MDR-TB in Europe: a multi-centre TBNET study Source: Annual Congress 2009 - Multi/extensively-drug resistant tuberculosis Year: 2009
Active case finding of tuberculosis in Europe: a Tuberculosis Network European Trials Group (TBNET) survey Source: Eur Respir J 2008; 32: 1023-1030 Year: 2008
Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study Source: ERJ Open Res, 8 (1) 00552-2021; 10.1183/23120541.00552-2021 Year: 2022
ERS/ECDC Statement: European Union standards for tuberculosis care, 2017 update Source: Eur Respir J, 51 (5) 1702678; 10.1183/13993003.02678-2017 Year: 2018