Anti-inflammatory effects of the JAK inhibitor tofacitinib in two murine house dust mite -driven models of asthma.

A. Pisano (Parma, Italy), D. Miglietta (Parma, Italy), F. Bignami (Parma, Italy), A. Allen (Parma, Italy), M. Biagetti (Parma, Italy), G. Aquino (Parma, Italy), C. Carnini (Parma, Italy), M. Civelli (Parma, Italy), G. Villetti (Parma, Italy)

Source: International Congress 2018 – Novel drug targets for asthma and COPD
Session: Novel drug targets for asthma and COPD
Session type: Oral Presentation
Number: 1941
Disease area: Airway diseases

Congress or journal article abstractWebcastSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Pisano (Parma, Italy), D. Miglietta (Parma, Italy), F. Bignami (Parma, Italy), A. Allen (Parma, Italy), M. Biagetti (Parma, Italy), G. Aquino (Parma, Italy), C. Carnini (Parma, Italy), M. Civelli (Parma, Italy), G. Villetti (Parma, Italy). Anti-inflammatory effects of the JAK inhibitor tofacitinib in two murine house dust mite -driven models of asthma.. 1941

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Involvement of apoptosis signal-regulating kinase-1 in house dust mite-induced allergic asthma in mice
Source: International Congress 2017 – "Alarming" immunological patterns in asthma
Year: 2017


Profiling the impact of two JAK inhibitors in a pre-clinical model of allergic asthma
Source: Virtual Congress 2020 – Scientific advances in airway pharmacology
Year: 2020


Implication of NOD-1 receptor in an experimental house dust mite-induced asthma model
Source: International Congress 2018 – Translational models of the immunopathology that underlies airway obstructive diseases
Year: 2018

Calcaratarin D attenuates house dust mite-induced allergic asthma
Source: Virtual Congress 2021 – Airway pharmacology: translational and basic science
Year: 2021


The effect of BCG treatment on the remodelling in the house dust mite induced allergic asthma in mice
Source: Eur Respir J 2005; 26: Suppl. 49, 580s
Year: 2005

The effect of montelukast during allergen sensitization period in house dust mite mouse model
Source: International Congress 2017 – "Alarming" immunological patterns in asthma
Year: 2017

House dust mite induces direct airway inflammation in vivo: implications for future disease therapy?
Source: Eur Respir J 2010; 35: 1377-1387
Year: 2010



Poly:IC causes exacerbation in a murine allergic inflammation model driven by house dust mite in Freund‘s complete adjuvant
Source: Annual Congress 2012 - Mechanisms and modulation of allergic inflammation in the lung
Year: 2012

Local lung house dust mite (HDM) challenges induce cell necrosis in mouse experimental asthma
Source: Virtual Congress 2020 – New insight into the immunology of asthma and COPD
Year: 2020


Impact of asthma-associated genetic polymorphisms on the efficacy of house dust mite sublingual allergy immunotherapy in adults with allergic asthma
Source: Virtual Congress 2021 – Asthma treatment: clinical and translational science
Year: 2021



The potent and lung-selective inhaled pan JAK inhibitor TD-8236 limits airway inflammation without affecting systemic immunity in mice
Source: International Congress 2019 – Novel targets and mechanisms in asthma
Year: 2019




Association between Th2 biomarker levels and efficacy of house dust mite sublingual allergy immunotherapy in adults with allergic asthma
Source: Virtual Congress 2021 – Asthma clinical trials and real-life studies
Year: 2021


Sublingual immunotherapy is an established therapy for house dust mite sensitive allergic rhinitis and/or asthma
Source: Annual Congress 2007 - Improving asthma therapy - new findings in established and experimental treatment modalities
Year: 2007


Safety of subcutaneous immunotherapy with standardized extracts of house dust mite in allergic asthmatic subjects
Source: Eur Respir J 2002; 20: Suppl. 38, 57s
Year: 2002

Effects of 3-yr immunotherapy with standardised extracts of house dust mite in allergic asthmatic subjects receiving appropriate drug treatment
Source: Eur Respir J 2002; 20: Suppl. 38, 107s
Year: 2002

Effect of house dust mite sublingual immunotherapy on airway inflammation and remodeling in allergic asthma with rhinitis
Source: International Congress 2019 – Precision meets immunology in treatment of airway diseases
Year: 2019




YS2: Role of Th9 cells in allergic airway inflammation induced by house dust mite
Source: Lung Science Conference 2011 - Immune system dysregulation in chronic lung disease
Year: 2011

A novel house dust mite-induced asthma model in guinea pigs driven by mast cells
Source: International Congress 2018 – Understanding the immunopathology that underlies airway obstructive diseases
Year: 2018



House dust mite sublingual immunotherapy reduces type 2 biomarkers in allergic asthma
Source: Virtual Congress 2020 – Management of allergy, asthma and COPD
Year: 2020


Models to mimic allergic asthma using house dust mite or Aspergillus fumigatus in mice: advantages and disadvantages
Source: Annual Congress 2005 - PG11 - Experimental models for COPD and asthma
Year: 2005