Genetic deficiency of α1-PI in mice influences lung responses to bleomycin

Cavarra E., Martorana P.A., Bartalesi B., Fineschi S., Gambelli F., Lucattelli M., Ortiz L., Lungarella G.

Source: Eur Respir J 2001; 17: 474-480
Journal Issue: March
Disease area: Interstitial lung diseases

Congress or journal article abstractPDF journal article, handout or slidesFull text journal article

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Cavarra E., Martorana P.A., Bartalesi B., Fineschi S., Gambelli F., Lucattelli M., Ortiz L., Lungarella G.. Genetic deficiency of α1-PI in mice influences lung responses to bleomycin. Eur Respir J 2001; 17: 474-480

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants
Source: Eur Respir J 2005; 25: 15-22
Year: 2005



Macrophages induce a divergent fibrotic response, in human lung fibroblasts, compared to TGF-ß alone
Source: International Congress 2017 – Cellular signalling pathways in pulmonary fibrosis
Year: 2017

Genetic variation of mouse responses to intratracheal challenge with LPS: lung injury, hyperinflation, and inflammation
Source: Eur Respir J 2005; 26: Suppl. 49, 559s
Year: 2005

Interferon-gamma (IFN-γ) alters the expression of IP-10 and IL-18 in human aveolar epithelial cells type II. Possible role in the reinforcement of Th1-dominated lung inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 521s
Year: 2001

Collagen phagocytosis by lung alveolar macrophages in animal models of emphysema
Source: Eur Respir J 2003; 22: 728-734
Year: 2003



Composition of the cellular matrix, nutrition, and hypoxia modulate the secretion and activation of collagenases and their inhibitors in human lung cells
Source: Eur Respir J 2001; 18: Suppl. 33, 244s
Year: 2001

Eosinophil cationic protein stimulates TGF-β1 release by human lung fibroblasts
Source: Annual Congress 2005 - Inflammation and remodelling in allergy and asthma
Year: 2005


Nasal tolerance promotes increase in tumoral type V collagen protein synthesis and vascular apoptosis in the mouse lung chemical carcinogenesis
Source: Annual Congress 2010 - Novel cellular mechanisms in lung disease
Year: 2010


PBI-compound, a novel first-in-class anti-fibrotic compound, inhibits CTGF and collagen production in murine and human fibroblasts, and reduces lung fibrosis in the bleomycin-induced lung fibrosis model
Source: Annual Congress 2013 –Cell signalling and inflammation: what's new in 2013?
Year: 2013


Genetic linkage analysis of pulmonary fibrotic response to silica in mice
Source: Eur Respir J 2006; 28: 1013-1019
Year: 2006



Inflammation and remodeling modulated by anti IL17 in model of lung injury induced by elastase in mice
Source: International Congress 2019 – Involvement of the environment and inflammation in pulmonary remodelling
Year: 2019

Differential gene expression and cytokine production from neutrophils in asthma phenotypes
Source: Eur Respir J 2010; 35: 522-531
Year: 2010



Soluble biglycan promotes ovalbumin induced airway inflammation by modulating dendritic cell function in mice
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of asthma
Year: 2019


Treatment with proteinase inhibitor, BbCI, modulates inflammatory response, mechanic alterations, and remodeling on elastase-induced emphysema in mice
Source: Annual Congress 2012 - The many roads to lung injury
Year: 2012

Alteration of eicosanoid metabolism/signalling in IL-9 overexpressing mice and impact on lung fibrosis
Source: Eur Respir J 2007; 30: Suppl. 51, 575s
Year: 2007

The expression of interleukin-13 gene is regulated by nfat1 in human T cells
Source: Annual Congress 2005 - Regulation of the allergic and asthmatic response
Year: 2005


Dose-dependent effects of muIL-13Rα2, a potent IL-13 neutraliser, on the phenotype of an acute allergic airways inflammation model in BALB/c mice
Source: Annual Congress 2004 - Animal models of asthma and chronic bronchitis and their relevance in pulmonary pharmacology
Year: 2004


Suppression of discoidin domain receptor 1 by RNA interference attenuates lung inflammation
Source: Annual Congress 2006 - Cellular immunology in asthma pathogenesis
Year: 2006


Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia
Source: Eur Respir J 2009; 33: 252-262
Year: 2009



Systemic inflammation, genetic susceptibility and lung function
Source: Eur Respir J 2008; 32: 92-97
Year: 2008