The effect of alcohol consumption in the treatment of nontuberculous mycobacteria M. Jacob (Porto, Portugal), R. Silva (Porto, Portugal), R. Gaio (Porto, Portugal), R. Duarte (Porto, Portugal), B. Ahlers (Bethany.Ahlers@uvm.edu / University of Vermont, V. Genetics Network,Burlington, V. , C. Hood (Catrina.Hood@uvm.edu / University of Vermont, V. Genetics Network,Burlington, V. , B. Deng (Bin.Deng@uvm.edu / University of Vermont, D. of Biology,Burlington, V. , Y. Lam (Ying-Wai.Lam@uvm.edu / University of Vermont, D. of Biology,Burlington, V. , E. Beatman (BeatmanE@NJHealth.org / National Jewish Health,Denver, C. , K. Schweitzer (SchweitzerK@NJHealth.org / National Jewish Health, D. of Pulmonary, C. Care and Sleep Medicine,Denver, C. , I. Petrache (PetracheI@NJHealth.org / National Jewish Health, D. of Pulmonary, C. Care and Sleep Medicine,Denver, C. , D. Weiss (daniel.weiss@uvm.edu / University of Vermont, C. of Medicine,Burlington, V. , D. Wagner (darcy.wagner@med.lu.se / Lund University,Lund)
Source: International Congress 2018 – Challenges in treating tuberculosis and nontuberculous mycobacteria
Disease area: Respiratory infectionsAbstract Background: the incidence of nontuberculous mycobacteria (NTM) disease is increasing and its presentation and severity can vary. Treatment of NTM disease is long, requires multiple drugs and the overall outcome can be related to host factors.
Aim: to identify the effect of the alcohol consumption on the treatment outcome, crude and adjusted for other host variables.
Methods: a retrospective analysis of patients with NTM disease between 2003-2016 (data from the Portuguese National Epidemiological Surveillance Commission for TB). Logistic regression models assessed odds ratios (OR) with 95% confidence interval (CI) for an unsuccessful treatment outcome.
Results: 610 patients were included, 540 (89%) had lung NTM disease. The average age was 58±18.2 years and 369 were male patients. Five hundred and seventeen (84.8%) patients finished treatment successfully (good outcome) and 93 (15.2%) died while in treatment (bad outcome). The crude OR for alcohol consumption was 3.48 (95% CI1.91-6.21 p<0.001). In multivariate analysis, alcohol consumption was associated with bad outcome (OR 2.01, 95%CI 1.05-3.87 p<0.001). This effect was adjusted for history of chronic lung disease and other co-morbidities (OR 2.78, 95%CI 1.22-4.63 p=0.013), cancer (OR 4.47, 95%CI 1.86-10.72, p=0.001), at least one previous treatment (OR 1.86, 95% CI1.01-3.43 p=0.023) and HIV-infection (OR 2.09, 95%CI 1.2-3.97 p=0.001). Female gender was significantly identified as protective factor.
Conclusion: after adjustment for potential risk factors, alcohol consumption was estimated to double the odds for an unsuccessful outcome. This underlines the need of close monitoring among patients with alcohol dependencies to improve treatment outcomes.
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M. Jacob (Porto, Portugal), R. Silva (Porto, Portugal), R. Gaio (Porto, Portugal), R. Duarte (Porto, Portugal), B. Ahlers (Bethany.Ahlers@uvm.edu / University of Vermont, V. Genetics Network,Burlington, V. , C. Hood (Catrina.Hood@uvm.edu / University of Vermont, V. Genetics Network,Burlington, V. , B. Deng (Bin.Deng@uvm.edu / University of Vermont, D. of Biology,Burlington, V. , Y. Lam (Ying-Wai.Lam@uvm.edu / University of Vermont, D. of Biology,Burlington, V. , E. Beatman (BeatmanE@NJHealth.org / National Jewish Health,Denver, C. , K. Schweitzer (SchweitzerK@NJHealth.org / National Jewish Health, D. of Pulmonary, C. Care and Sleep Medicine,Denver, C. , I. Petrache (PetracheI@NJHealth.org / National Jewish Health, D. of Pulmonary, C. Care and Sleep Medicine,Denver, C. , D. Weiss (daniel.weiss@uvm.edu / University of Vermont, C. of Medicine,Burlington, V. , D. Wagner (darcy.wagner@med.lu.se / Lund University,Lund). The effect of alcohol consumption in the treatment of nontuberculous mycobacteria. 539
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