CHF6366: characterisation of the bronchoprotective effect of a novel MABA compound in the experimental bronchospasm model in anaesthetised guinea pigs

D. Miglietta (PARMA, PR, Italy)

Source: International Congress 2017 – Novel studies on bronchodilators and cough
Session: Novel studies on bronchodilators and cough
Session type: Oral Presentation
Number: 4405
Disease area: Airway diseases

Congress or journal article abstractWebcastSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
D. Miglietta (PARMA, PR, Italy). CHF6366: characterisation of the bronchoprotective effect of a novel MABA compound in the experimental bronchospasm model in anaesthetised guinea pigs. 4405

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The bronchodilator effects of the novel anti-inflammatory compound TPI 1020, alone and in combination with formoterol, in conscious guinea pigs
Source: Annual Congress 2009 - Preclinical models in drug development
Year: 2009


A novel TRPA1 antagonist inhibits ovalbumin-induced bronchoconstriction in guinea pig models
Source: International Congress 2019 – Airway inflammation: pharmacological mechanisms and novel targets
Year: 2019

Effect of SMP-028, a novel anti-inflammatory agent, on experimental allergic asthma in guinea pig model
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Alpha-1L, but not alpha-1H, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivo
Source: Eur Respir J 2001; 18: Suppl. 33, 104s
Year: 2001

Selective PDE inhibitors in modulation of cough reflex and bronchoconstriction in healthy and ovalbumin-sensitized guinea pigs
Source: Annual Congress 2010 - Models of airways disease
Year: 2010


Late asthmatic response is modulated by TRPA1 antagonists in ovalbumin-induced bronchoconstriction in anaesthetized guinea pigs
Source: Annual Congress 2012 - New drug targets and pre-clinical models for respiratory diseases
Year: 2012


AWD 12-281, a new PDE4-inhibitor, suppresses allergen-induced [DCquote]early phase“ bronchoconstriction in sensitized guinea pigs
Source: Eur Respir J 2003; 22: Suppl. 45, 107s
Year: 2003

Compound X – an inhaled β2 agonist with equivalent potency and superior duration of action (DOA)/ therapeutic index (TI) to salmeterol in the anaesthetised dog model of bronchoconstriction
Source: Annual Congress 2008 - Novel treatments for respiratory disease
Year: 2008

Changes of chemically induced cough and specific airway resistance during capsaicin nasal challenge in awake guinea pigs
Source: Eur Respir J 2001; 18: Suppl. 33, 85s
Year: 2001

Prevention of induced bronchoconstriction in sensitized guinea pigs: efficacy of common prophylactic drugs
Source: Eur Respir J 2003; 22: Suppl. 45, 99s
Year: 2003

The effects of repeated nasal allergen challenge on cough response in sensitized guinea pigs
Source: Eur Respir J 2003; 22: Suppl. 45, 475s
Year: 2003

A novel dual-agonist challenge model in guinea pigs for assessment of individual and combined muscarinics antagonists and b2 adrenoceptor agonists bronchodilator efficacy
Source: Annual Congress 2011 - Models of disease and drug actions
Year: 2011

Pathogenic effect of intratracheal exposure on nanocarbons - in vivo study on guinea pig model
Source: Eur Respir J 2004; 24: Suppl. 48, 606s
Year: 2004

Effect of chronic ovalbumin sensitization on bronchoconstriction induced by hyperventilation in guinea pigs
Source: Eur Respir J 2001; 18: Suppl. 33, 103s
Year: 2001

Discovery of competitive thromboxane receptor (TP) antagonism by diclofenac in guinea pig airway and vascular tissues
Source: Annual Congress 2007 - Recent advances in airway smooth muscle biology
Year: 2007


Alternative method to profile slow onset bronchodilators in guinea pig trachea in vitro for potency and pKB analysis
Source: Eur Respir J 2004; 24: Suppl. 48, 127s
Year: 2004

Antagonism by reproterol of adenosine-mediated tension responses in isolated guinea pig trachea
Source: Eur Respir J 2003; 22: Suppl. 45, 106s
Year: 2003

The benefit of new antileukotriene derivatives on airway responsiveness in ovalbumin-sensitized rats
Source: Eur Respir J 2004; 24: Suppl. 48, 219s
Year: 2004

The inhaled anticholinergic agent, aclidinium bromide, reverses cholinergic-induced bronchoconstriction in guinea pigs with a fast onset of action and a long duration of effect
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD
Year: 2008


Assessment of the potency and duration of action of aclidinium bromide in guinea pig isolated trachea in vitro
Source: Annual Congress 2007 - Recent advances in our understanding of the mechanisms of asthma treatment
Year: 2007