Elevated integrin ?5 expression in idiopathic pulmonary fibrosis (IPF) derived fibroblasts is linked to paracrine TNF-a signaling

G. Epstein Shochet (Kfar-Saba, Israel)

Source: International Congress 2017 – Cellular signalling pathways in pulmonary fibrosis
Session: Cellular signalling pathways in pulmonary fibrosis
Session type: Poster Discussion
Number: 3479
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
G. Epstein Shochet (Kfar-Saba, Israel). Elevated integrin ?5 expression in idiopathic pulmonary fibrosis (IPF) derived fibroblasts is linked to paracrine TNF-a signaling. 3479

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The role of IL-10 receptors in aberrant homeostatic control of TNF-α in idiopathic pulmonary fibrosis (IPF)
Source: Eur Respir J 2002; 20: Suppl. 38, 599s
Year: 2002

RhoA signalling influences cyclin D1 expression and associated fibroblast turnover: implications for idiopathic pulmonary fibrosis (IPF)
Source: Annual Congress 2006 - Lung vascular and parenchymal remodeling
Year: 2006


Differential expression of stromal cell derived factor-1/CXC chemokine receptor 4 (SDF-1/CXCL12 – CXCR4) biological axis between idiopathic pulmonary fibrosis and interstitial pneumonia associated with collagen vascular disease: a bronchoalveolar la
Source: Annual Congress 2008 - Interstitial lung disease in systemic and vascular disorders
Year: 2008

NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFβ1-induced fibroblast differentiation into myofibroblasts
Source: Annual Congress 2009 - From emphysema to fibrosis: mechanisms of cellular remodelling in the diseased lung
Year: 2009

Altered expression of adhesion molecules in circulating neutrophils of patients with idiopathic pulmonary fibrosis
Source: Eur Respir J 2002; 20: Suppl. 38, 479s
Year: 2002

Down regulation of stromal cell-derived factor 1 (SDF-1/CXCL12) in lung tissue of patients with idiopathic pulmonary fibrosis
Source: Eur Respir J 2007; 30: Suppl. 51, 574s
Year: 2007

Upregulation of interleukin 13 receptor alpha 2 (IL-13RA2) expression in idiopathic pulmonary fibrosis
Source: Eur Respir J 2005; 26: Suppl. 49, 267s
Year: 2005

Elevated serum B cell activating factor belonging to the TNF family (BAFF) in interstitial lung diseases associated with collagen vascular disease
Source: Annual Congress 2012 - Diffuse parenchymal lung disease: clinical profiles and collagen vascular disease
Year: 2012

Epidermal growth factor receptor (EGFR) activation is required for TGFbeta1-induced epithelial-mesenchymal transition (EMT) in idiopathic pulmonary fibrosis (IPF)
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013

Reactivation of developmental pathways in idiopathic pulmonary fibrosis: FGF9 and FGF18 modulate the phenotype of control and fibrotic human lung fibroblasts in vitro
Source: International Congress 2015 – IPF: from bench to bedside
Year: 2015

Expression of angiogenic growth factors and stromal cell derived factor-1/CXC chemokine receptor 4 (SDF-1/CXCL12 – CXCR4) biological axis in idiopathic pulmonary fibrosis: a lung tissue study
Source: Annual Congress 2008 - New insights into the pathogenesis of idiopathic pulmonary fibrosis and sarcoidosis
Year: 2008


The matrix-fibroblast interplay contributes to HIF-1 alpha pathway activation: a possible therapeutic target in idiopathic pulmonary fibrosis (IPF)
Source: Virtual Congress 2020 – Elucidating the mechanisms underlying lung repair and exploring therapeutic strategies in vitro
Year: 2020




Inhibition of HGF secretion by pulmonary fibroblasts from IPF: involvement of PGE2
Source: Eur Respir J 2003; 22: Suppl. 45, 8s
Year: 2003

Down-regulation of inhibitory of growth family member 4(ING4) in idiopathic pulmonary fibrosis (IPF). Correlation with disease progression
Source: Annual Congress 2009 - Pathogenesis of pulmonary fibrosis
Year: 2009


Upregulation of Fas-signalling molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis
Source: Eur Respir J 2001; 17: 180-189
Year: 2001



Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: Role of transmembrane SCF and PAR-2/PKCalpha/Raf-1/p44/42 signaling pathway
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis and rarities
Year: 2013

LSC Abstract – Activation of FGF9 and 18 in idiopathic pulmonary fibrosis promote survival and migration and inhibit myofibroblast differentiation of human lung fibroblasts
Source: International Congress 2016 – Common mechanisms in lung development and fibrosis
Year: 2016

Enhanced expression of IL-18 receptor but not soluble form of IL18R in chronic obstructive pulmonary disease (COPD)
Source: Annual Congress 2011 - COPD: clinical studies and animal cell models
Year: 2011

Expression of mRNA of selected inflammatory markers in BALf cells from patients with sarcoidosis and idiopathic pulmonary fibrosis (IPF)
Source: International Congress 2017 – IPF: from the bench to the bedside
Year: 2017

Treprostinil effectively inhibits PDGF and TGF-ß1 induced extracellular matrix composition by IPF fibroblasts
Source: International Congress 2015 – Therapeutic approaches in inflammatory lung disease
Year: 2015