The potent and lung-selective inhaled pan JAK inhibitor TD-8236 limits airway inflammation without affecting systemic immunity in mice Source: International Congress 2019 – Novel targets and mechanisms in asthma Year: 2019
Inhibition of c-kit tyrosine kinase by sunitinib alleviates airway remodeling in a mouse model of chronic asthma Source: Annual Congress 2009 - Preclinical models in drug development Year: 2009
The pan janus kinase (JAK) inhibitor KN-002 suppresses inflammatory mediator release from severe asthma bronchial epithelial cells. Source: Virtual Congress 2021 – Airway pharmacology: translational and basic science Year: 2021
Decreased peribronchial fibrosis in chronic ovalbumin-induced asthma model of PI3K deficiency mice Source: Eur Respir J 2005; 26: Suppl. 49, 26s Year: 2005
Activated protein C inhibits bronchial inflammation and hyperresponsiveness in a mouse model of asthma Source: Eur Respir J 2002; 20: Suppl. 38, 618s Year: 2002
Ceramide-1-phosphate decreases allergic airway inflammation, remodeling and hyperresponsiveness by inhibition of phosphorilation of NF-kappa B, Akt, MAPK p-38 in dendritic cells Source: Annual Congress 2010 - Models of airways disease Year: 2010
AZD7624, an inhaled p38 inhibitor for COPD, attenuates lung and systemic inflammation after LPS Challenge in humans Source: International Congress 2015 – Advances in the future treatment of COPD Year: 2015
A phosphatidylinositol 3-kinase Inhibitor strongly suppressed pulmonary vascular remodeling in a murine model of allergic vasculitis Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions Year: 2015
A dual role of IL-6 signalling and STAT-3 activation on airway inflammation versus airway hyperresponsiveness in a murine model of asthma Source: Eur Respir J 2002; 20: Suppl. 38, 568s Year: 2002
The selective Rho kinase inhibitor trans-6-((4-aminocyclohexyl)amino)-5-fluoro-2-methoxynicotinamide ameliorates experimental pulmonary hypertension Source: International Congress 2017 – Experimental PH Year: 2017
Role of Rho kinase isoforms in murine allergic airway responses Source: Eur Respir J 2011; 38: 841-850 Year: 2011
The p38 MAP kinase inhibitor dilmapimod ameliorates airway inflammation induced by ozone challenge in healthy volunteers Source: Annual Congress 2012 - Treatment of asthma, bronchiectasis and cough: inhaler use Year: 2012
Treatment with Syk inhibitors after establishment of disease phenotype in a chronic HDM model of allergic airways inflammation abolishes AHR and attenuates inflammatory mediator expression Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD Year: 2015
Inhibition of P38 kinase does not reduce production of TNF-alpha from airway cells in COPD Source: Annual Congress 2007 - Epithelial networks in the airways Year: 2007
STAT4 activation in smokers and patients with chronic obstructive pulmonary disease Source: Eur Respir J 2004; 24: 78-85 Year: 2004
HIF-1α inhibitor, 2ME2, attenuates airway inflammation and hyperresponsiveness in allergic airway disease Source: Annual Congress 2008 - Novel therapeutic approaches and immunological mechanisms in airway cell pathobiology Year: 2008
Inhibition of VEGF blocks the activation of TGF-β1 through a PI3K/Akt signaling pathway in allergic airway disease of mice Source: Annual Congress 2007 - Current issues in airway physiology, pharmacology and monitoring Year: 2007
Caspase-1 deficiency reduces eosinophilia and interleukin-33 in an asthma exacerbation model Source: ERJ Open Res, 3 (4) 00047-2017; 10.1183/23120541.00047-2017 Year: 2017
Inhibition of Pim1 kinase, new therapeutic approach in virus-induced asthma exacerbations Source: Eur Respir J 2016; 47: 783-791 Year: 2016
NLRP3 inflammasome is activated via phosphoinositide 3-kinase δ pathway in Aspergillus fumigatus-induced allergic airway inflammation Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions Year: 2015