Inhibition of dynein motors improves macrophage phagocytosis in COPD

K. Anders (London, United Kingdom)

Source: International Congress 2017 – Infection and exacerbation science
Session: Infection and exacerbation science
Session type: Thematic Poster
Number: 981
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. Anders (London, United Kingdom). Inhibition of dynein motors improves macrophage phagocytosis in COPD. 981

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Differential phosphorylation patterns of macrophage cytoskeletal proteins in COPD following phagocytosis
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of COPD
Year: 2019

Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages
Source: Eur Respir J, 54 (4) 1802244; 10.1183/13993003.02244-2018
Year: 2019



NDP52 inhibition rescues cigarette smoke mediated impairment of autophagy in macrophages
Source: International Congress 2016 – New therapies and therapeutic targets
Year: 2016

Mitochondrial dysfunction in macrophages: a key to defective bacterial phagocytosis in COPD
Source: Eur Respir J, 54 (4) 1901641; 10.1183/13993003.01641-2019
Year: 2019



LATE-BREAKING ABSTRACT: Defective macrophage phagocytosis in COPD is associated with reduced STAT1 phosphorylation
Source: Annual Congress 2012 - Molecular biology of pro- and anti-inflammatory responses in the lung
Year: 2012

Inhibition of uPA-uPAR signaling restores respiratory epithelial barrier function in asthma and COPD
Source: International Congress 2019 – Cellular responses and cell therapy in lung injury and repair
Year: 2019

JAK/STAT inhibition improves macrophage phagocytosis of bacteria
Source: Annual Congress 2011 - Macrophages and neutrophils in chronic lung disease
Year: 2011

Altered scavenger receptor expression and response to oxidative stress is linked to defective bacterial phagocytosis in COPD macrophages
Source: International Congress 2016 – Mechanisms of disease
Year: 2016

Targeted NF-κB inhibition of asthmatic serum-mediated human monocyte-derived dendritic cell differentiation in a transendothelial trafficking model
Source: Annual Congress 2009 - Inflammatory cells and cytokines
Year: 2009


BALF modulates neutrophil phagocytosis and ROS production in different ways
Source: Annual Congress 2009 - Airway inflammation and host defence
Year: 2009

Inhibition of the Arp2/3 complex inhibits lung myofibroblast differentiation in vitro and attenuates bleomycin-induced pulmonary fibrosis in mice
Source: International Congress 2019 – Extracellular matrix formation and remodelling in physiology and disease
Year: 2019

Increased expression of sphingosine-1-phosphate and S1PR2 are associated with attenuated macrophage phagocytosis in COPD
Source: Annual Congress 2013 –COPD: experimental biology
Year: 2013

Cigarette smoke switches epithelial cell apoptosis into necrosis by inhibition of ATP production through a blockade of the mitochondrial respiratory chain
Source: Eur Respir J 2006; 28: Suppl. 50, 605s
Year: 2006

Effect of diesel exhaust particles (DEP) on monocyte-derived macrophage (MDM) mediator release and phagocytosis in chronic obstructive pulmonary disease (COPD)
Source: Annual Congress 2013 –COPD: experimental biology
Year: 2013

Different inhaled corticosteroids altered lung microbiome and regulating the expression of PAF receptor as well as the phagocytosis function of macrophage
Source: International Congress 2019 – Host-microbe interactions in lung disease and exacerbations
Year: 2019

Phosphoinositide 3-kinase γ required for lipopolysaccharide-induced transepithelial neutrophil trafficking in the lung
Source: Eur Respir J 2010; 35: 1137-1147
Year: 2010



Monocyte-derived macrophages from non-smoker COPD subjects exhibit defective bacterial phagocytosis
Source: International Congress 2015 – Mucosal immunology: what’s new in 2015
Year: 2015


Neutrophil extracellular trap formation is regulated by CXCR2 in COPD neutrophils
Source: Eur Respir J, 51 (4) 1700970; 10.1183/13993003.00970-2017
Year: 2018



Impaired efferocytosis and neutrophil extracellular trap clearance by macrophages in ARDS
Source: Eur Respir J, 52 (2) 1702590; 10.1183/13993003.02590-2017
Year: 2018



Reduced phagocytosis of pathogenic bacteria by neutrophils from COPD patients
Source: Annual Congress 2012 - Update on neutrophil and macrophage function in COPD
Year: 2012