Involvement of MMP-12 and phosphodiesterase type 4 in cigarette smoke-induced inflammation in mice

Leclerc O., Lagente V., Planquois J-M., Berthelier C., Artola M., Eichholtz T., Bertrand C. P., Schmidlin F.

Source: Eur Respir J 2006; 27: 1102-1109
Journal Issue: June
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Leclerc O., Lagente V., Planquois J-M., Berthelier C., Artola M., Eichholtz T., Bertrand C. P., Schmidlin F.. Involvement of MMP-12 and phosphodiesterase type 4 in cigarette smoke-induced inflammation in mice. Eur Respir J 2006; 27: 1102-1109

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Role of lymphotoxin-alpha in cigarette smoke-induced inflammation and lymphoid neogenesis
Source: Eur Respir J 2009; 33: 405-416
Year: 2009



A neutrophil elastase inhibitor reduces cigarette smoke-induced remodelling of lung vessels
Source: Eur Respir J 2003; 22: 77-81
Year: 2003



Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space
Source: Eur Respir J 2008; 32: 644-650
Year: 2008



Role of IL-1? and the Nlrp3/caspase-1/IL-1? axis in cigarette smoke-induced pulmonary inflammation and COPD
Source: Eur Respir J 2011; 38: 1019-1028
Year: 2011



Cigarette smoke-induced pulmonary inflammation, but not airway wall remodeling, is attenuated in CCR5 deficient mice
Source: Annual Congress 2007 - The best of airway epithelial cells
Year: 2007



PDE4 inhibition prevents corticosteroid-resistant lung inflammation induced by cigarette smoke exposure in mice
Source: Annual Congress 2009 - Highlighting the epithelial cell in lung disease: from COPD to cancer to acute lung injury
Year: 2009


A selective MMP-12 inhibitor, MV062926, reduces inflammatory responses to cigarette smoke in mice
Source: Annual Congress 2010 - Pre-clinical models of airways disease
Year: 2010



Cigarette smoke induced pulmonary emphysema is attenuated in CCR6 deficient mice
Source: Annual Congress 2006 - Cell biology of asthma and COPD
Year: 2006


Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition
Source: Eur Respir J 2013; 41: 1264-1274
Year: 2013



Cytokine and chemokine expression in cigarette smoke-induced lung injury in guinea pigs
Source: Eur Respir J 2005; 26: 993-1001
Year: 2005



Susceptibility to tobacco smoke related to protease inhibitor PIM subtypes in COPD
Source: Annual Congress 2005 - What's new in tobacco and lung disease
Year: 2005


Characterisation of a sub-acute mouse model of cigarette smoke extract-induced lung inflammation
Source: Annual Congress 2007 - The best of airway epithelial cells
Year: 2007


Cigarette smoking inhibits LTA4H aminopeptidase activity and contributes to chronic neutrophilic airway inflammation and COPD
Source: Annual Congress 2011 - COPD: clinical studies and animal cell models
Year: 2011


Cigarette smoke induces peribronchial lymphoid follicles in the absence of TLR4 signalling
Source: Annual Congress 2006 - Cell biology of asthma and COPD
Year: 2006


Role of tumour necrosis factor-α receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema
Source: Eur Respir J 2006; 28: 102-112
Year: 2006



Matrix metalloproteinases in COPD
Source: Eur Respir J 2012; 39: 197-209
Year: 2012



Matrix metalloproteinases in COPD
Source: Eur Respir J 2011; 39: 197-209
Year: 2012



Inhibition of lung inflammation by a protein epitope mimetic (PEM) neutrophil elastase inhibitor, POL6014, in a sub-chronic tobacco smoke (TS) model in mice
Source: Annual Congress 2013 –Novel drugs for the treatment of asthma and COPD
Year: 2013


An inhaled MMP inhibitor blocks cigarette-induced lung damage in the smoking mouse model
Source: Annual Congress 2003 - Cigarette smoke: how it does its dirty work
Year: 2003


Human macrophage elastase (MMP-12) expression in human emphysematous lungs: role in extracellular matrix remodelling in chronic obstructive pulmonary diseases (COPD)
Source: Eur Respir J 2001; 18: Suppl. 33, 501s
Year: 2001