An oral selective M3 cholinergic receptor antagonist in COPD

Lu S., Parekh D. D., Kuznetsova O., Green S. A., Tozzi C. A., Reiss T. F.

Source: Eur Respir J 2006 Oct 01;28(4):772-780
Journal Issue: October
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Lu S., Parekh D. D., Kuznetsova O., Green S. A., Tozzi C. A., Reiss T. F.. An oral selective M3 cholinergic receptor antagonist in COPD. Eur Respir J 2006 Oct 01;28(4):772-780

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Repeated-dose pharmacokinetics of once-daily TD-4208, a long-acting muscarinic receptor antagonist (LAMA), in subjects with COPD
Source: International Congress 2014 – Bronchodilators for asthma and COPD
Year: 2014


Efficacy and safety of aclidinium bromide, a novel long-acting muscarinic antagonist, in patients with moderate to severe COPD
Source: Annual Congress 2009 - New bronchodilators
Year: 2009

Dose-related efficacy of GSK573719, a new long-acting muscarinic receptor antagonist (LAMA) offering sustained 24-hour bronchodilation, in COPD
Source: Annual Congress 2011 - Bronchodilators in asthma and COPD
Year: 2011

Phase II study of once-daily GSK573719 inhalation powder, a new long-acting muscarinic antagonist, in patients with chronic obstructive pulmonary disease (COPD)
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics I
Year: 2011

Combination of beta2 agonists and anticholinergic drugs improves lung function in patients with COPD
Source: Eur Respir J 2006; 28: Suppl. 50, 726s
Year: 2006

Paradoxical bronchoconstriction after administration of beta-2 agonist bronchodilators in COPD patients
Source: Virtual Congress 2021 – Biomarkers to phenotype COPD: prediction of exacerbations
Year: 2021


Comparison of the efficacy and safety of long-acting anticholinergic and a combination of inhaled steroids and long-acting beta-2 agonist in moderate chronic obstructive pulmonary disease
Source: Annual Congress 2013 –COPD drugs: new findings
Year: 2013

Effect of long-acting muscarinic antagonist (LAMA) on 24-hour physical behaviours in COPD
Source: Virtual Congress 2020 – Reviews and novel insights into pulmonary rehabilitation
Year: 2020


The role of bronchodilator treatment in the prevention of exacerbations of COPD
Source: Eur Respir J 2012; 40: 1545-1554
Year: 2012



The efficacy and safety of long-acting muscarinic antagonist treatment for COPD
Source: International Congress 2019 – Advances in chronic obstructive pulmonary disease and asthma
Year: 2019


Rate of onset of action of aclidinium bromide, a novel, long-acting, muscarinic antagonist
Source: Annual Congress 2009 - Next generation bronchodilators
Year: 2009


In chronic obstructive pulmonary disease, a combination of ipratropium and long-acting beta2-agonists is more effective than either agent alone
Source: Eur Respir J 2001; 18: Suppl. 33, 211s
Year: 2001

Efficacy and safety of twice-daily aclidinium bromide in COPD patients: the ATTAIN study},
Source: Eur Respir J 2012; 40: 830-836
Year: 2012



Long-acting muscarinic antagonists: a potential add-on therapy in the treatment of asthma?
Source: Eur Respir Rev 2015; 25: 54-64
Year: 2016



Efficacy and tolerability of NVA237, a once daily long-acting muscarinic antagonist, in COPD patients
Source: Annual Congress 2007 - Mechanisms and new treatments of COPD
Year: 2007


Association of cardiovascular risk with inhaled long-acting anti-muscarinic antagonists in COPD patients with impaired renal function
Source: International Congress 2018 – Cardiovascular morbidities in COPD
Year: 2018


In vitro pharmacological profile of CHF 5407, a potent, long-acting and selective muscarinic M3 receptor antagonist
Source: Eur Respir J 2007; 30: Suppl. 51, 25s
Year: 2007

Efficacy and safety of NVA237 versus placebo and tiotropium in patients with COPD: the GLOW2 study
Source: Eur Respir J 2012; 40: 1106-1114
Year: 2012



Reducing cholinergic constriction: the major reversible mechanism in COPD
Source: Eur Respir Rev 2006; 15: 32-36
Year: 2006



Safety and tolerability of NVA237, a once daily long-acting muscarinic antagonist, in patients with COPD
Source: Annual Congress 2008 - Novel treatments for respiratory disease
Year: 2008