Source: Annual Congress 2001 - Molecular and cellular pathology of asthma
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Chronic bronchiolitis (CB) is characterized by inflammatory process in low airways. Such cytokines as INF-γ and multifunctional pro-inflammatory cytokine TNF-α can regulated a wide spectrum of alveolar macrophage activity in immune answer and inflammation.
The aim of the study was to determine TNF-α and INF-γ levels in brohchoalveolar lavage fluid (BALF) and blood serum in patients with CB.
We study 57 children (age 11.5±]0.4 years) with CB in exacerbation and remission periods. All patients were divided into 3 groups on degree of bronchial obstruction: 15 patients had severe variant of CB (1 group), 15 -had moderate variant (II group) and 27 children had mild variant of illness (III group).
BAL-fluid and serum levels of TNF-α in exacerbation period were significantly higher in patients with severe variant CB (I group) as compare to patients of II and III groups. Levels of INF-γ in BAL-fluid of patients with CB were in normal range (20.2 ±]2.7 pg/ml).
In blood serum it was detected negative correlation of level of INF- and degree of bronchial obstruction in exacerbation period: in patients of III group it was detected significantly(P<0.01) higher INF-γ levels as compare to I group.
The data obtained indicate that TNF-α levels in BAL-fluid and blood serum can be used as a marker of a severity of chronic bronchiolitis.

group of patients	TNFα in BALF (pg/ml)(exacebration)	TNFα in BALF (pg/ml)(remission)	TNFα in blood serum (pg/ml)(exacebration)	TNFα in blood serum (pg/ml)(remission)	INFγ in blood serum (pg/ml) (exacebration)	INFγ in blood serum (pg/ml) (remission)
I	562,5±]51,6	118,6±]17,7	134,3±]19,9	87,5±]10,2	65,7±]15,1	57,0±]11,2
II	362,5±]42,9	113,4±]21,9	53,4±]8,7	40,3±]7,1	80,2±]11,3	75,8±]12,4
III	250,4±]48,5	119,0±]20,1	44,7±]9,5	29,5±]5,1	129,5±]13,4	87,4±]13,4

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Citations should be made in the following way:
G. Muryghina, T. Ses, E. Boitsova, A. Bogdanova (St. Petersburg, St.Petersburg, Russia). Levels of tumour necrosis factor and interferon in bronchoalveolar lavage fluid and blood serum in children with chronic bronchiolitis. Eur Respir J 2001; 16: Suppl. 31, 3558

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