Source: Annual Congress 2001 - Cardiovascular pathophysiology in OSA
Disease area: Sleep and breathing disorders

Abstract

Abnormal baroreflex sensitivity (BRS) has prognostic value in a variety of cardiovascular diseases and may be important in the development of hypertension. Obstructive sleep apneoa (OSA) patients are reported to have depressed baroreflex sensitivity which may contribute to the raised blood pressure seen in these patients. We measured awake resting BRS (ms / mmHg) using the bolus phenylephrine technique in 55 men with OSA (Epworth sleepiness score (ESS) >= 10, with > 10 > 4% oxygen desaturations per hour), before and after 4-weeks of therapeutic CPAP (n= 25), or sub-therapeutic CPAP as a control (n=30). BRS slopes and change following treatment were compared between groups using independent t tests. Baseline variables were similar between groups; Age mean (sd) 49.1 (8.0), body mass index 33.9 (5.4), ESS 15.4 (2.9), SaO₂ dip rate 41.3 (22.3) per hour. At baseline BRS was similar between groups, therapeutic 7.1 (3.8)ms/mmHg, sub-therapeutic 6.2 (3.2), p=0.5. Both the change in BRS and post treatment BRS were different in the therapeutic group compared to control. Therapeutic change +1.02 (3.8), sub-therapeutic -0.7 (2.4), p=0.004. Post treatment BRS therapeutic 8.3 (4.2), sub-therapeutic 5.5 (2.5), p=0.05. BRS improves in OSA patients treated with CPAP compared to a robust control.

Rating:

Share or cite this content

Citations should be made in the following way:
J. C. T. Pepperell, S. R-Dow, N. R. Crosthwaite, N. A. Maskell, J. R. Stradling, R. J. O. Davies (Oxford, United Kingdom). Baroreflex sensitivity in obstructive sleep apnoea and its change after 4 weeks continuous positive airway pressure. Eur Respir J 2001; 16: Suppl. 31, 3497

Member's Comments

No comment yet.

Related content which might interest you: Erratic adherence to continuous positive airway pressure for obstructive sleep apnea Source: International Congress 2018 – From continuous positive airway pressure (CPAP) and adherence to CPAP to asthma-COPD overlap syndrome (ACOS) Year: 2018 Long-term continuous positive airway pressure compliance in females with obstructive sleep apnoea Source: Eur Respir J 2013; 42: 1255-1262 Year: 2013 Evaluation of continuous positive airway pressure compliance in a group of obstructive sleep apnea patients Source: Annual Congress 2012 - Clinical predictors of OSA, adherence to CPAP and psychology Year: 2012 Adherence to continuous positive airway pressure in women with obstructive sleep apnoea Source: International Congress 2017 – Efficacy of and compliance with obstructive sleep apnoea treatment Year: 2017 Gender-related differences in compliance with continuous positive airway pressure for obstructive sleep apnea Source: Annual Congress 2008 - Metabolic and sex-related aspects of obstructive sleep apnoea Year: 2008 Residual sleep-disordered breathing during autotitrating continuous positive airway pressure therapy Source: Eur Respir J 2012; 39: 1391-1397 Year: 2012 Snoring detection during auto-nasal continuous positive airway pressure Source: Eur Respir J 2002; 19: 108-112 Year: 2002 Blood pressure responsiveness to obstructive events during sleep after chronic CPAP Source: Eur Respir J 2003; 21: 509-514 Year: 2003 Predictors of sleepiness in obstructive sleep apnoea at baseline and after 6 months of continuous positive airway pressure therapy Source: Eur Respir J, 50 (5) 1700348; 10.1183/13993003.00348-2017 Year: 2017 Cardiac sympathovagal balance during sleep in obstructive sleep apnea patients is different under auto-adjusting CPAP than fixed-CPAP treatment Source: Annual Congress 2006 - Therapeutic effects in obstructive sleep apnoea Year: 2006 Baroreflex control of heart rate during sleep in severe obstructive sleep apnoea: effects of acute CPAP Source: Eur Respir J 2006; 27: 128-135 Year: 2006 Liver function following continuous positive airway pressure therapy in obstructive sleep apnea patients Source: International Congress 2017 – CPAP therapy Year: 2017 Continuous positive airway pressure in patients with obstructive sleep apnea: Age-dependent adherence Source: Annual Congress 2010 - Clinical aspects of sleep apnoea Year: 2010 Treatment of obstructive sleep apnoea with nasal continuous positive airway pressure in stroke Source: Eur Respir J 2001; 18: 623-629 Year: 2001 Proportional positive airway pressure: a new concept to treat obstructive sleep apnoea Source: Eur Respir J 2001; 17: 467-473 Year: 2001 Efficacy of an automatic positive airway pressure system for treatment of obstructive sleep apnoea Source: Eur Respir J 2002; 20: Suppl. 38, 9s Year: 2002 Index for comfort of patients with obstructive sleep apnea on continuous positive airway pressure therapy Source: Annual Congress 2008 - Clinical aspects of continuous positive airway pressure therapy Year: 2008 Continuous positive airway pressure in patients with obstructive sleep apnea: Adherence dependent on apnea-hypopnea index, leakage and mask pressure Source: Annual Congress 2011 - Epidemiology, diagnosis and treatment in obstructive sleep apnoea Year: 2011 Adherence to positive airway pressure in non-sleepy patients with obstructive sleep apnoea Source: Eur Respir J 2013; 42: 863-866 Year: 2013 Predictive equation for optimal continuous positive airway pressure in children with obstructive sleep apnoea Source: ERJ Open Res, 6 (2) 00312-2019; 10.1183/23120541.00312-2019 Year: 2020