Source: Annual Congress 2001 - Thoracoscopy

Abstract

Many reports have shown that talc is the most effective and less expensive agent for creation of pleural symphysis. However it use still remains a controversial issue due to severe respiratory side effects possibly relating to systemic distribution of talc particles. This study was performed to determine the distribution of calibrated talc after intrapleural administration.
Thirty-three rats underwent injection by 40 mg of calibrated talc (Novatech-France) suspended in 1 ml of sterile salin solution. The animals were randomly assigned for autopsy at 24 or 72 hours after pleural injection. Lungs, parietal pleura, diaphragm, liver, kidneys, spleen, pericardium, brain, and blood were assessed by light microscopy and submitted to polarized light for birefringent particles analysis.
No deaths were observed. Since the autopsies showed no pleurodesis at 24 and 72 h. In two animals, a few talc particles were found in the liver and in one animal in the spleen. No particles were found in the others organs and in particular in the brain and the blood as previously described.
These results are probably due to the size of the talc particles used which is superior to 5 microns in diameter for more than 95% of the particles (Median: 15 microns). Calibrated talc is requiered in case of intrapleural administration to avoid systemic distribution and secondary respiratory effects.

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Citations should be made in the following way:
A. Fraticelli, A. Robaglia, P. Cau, P. Astoul (Marseille, France). Distribution of calibrated talc after intrapleural administration: an experimental study. Eur Respir J 2001; 16: Suppl. 31, 3479

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