Source: Annual Congress 2001 - Drug resistant TB
Disease area: Respiratory infections

Abstract

The aim of the study is to assess the effectiveness of standard WHO re-treatment regimen ( 2 HRZES / 1 HRZE / 5 HRE ) for pulmonary tuberculosis patients who have interrupted their commenced treatment ( Group A) or presented with a relapse following completion of standard therapy ( Group B ) From January 1998 to April 2000, 50 patients ( Group A=33 and Group B=17 ) were included in the study. There were 45 male and 5 female. Of 48 patients in whom drug susceptibility tests were performed, 26 (54%) were sensitive to all drugs, 22 (46%) were resistant to at least one drug, 6 (13%) were resistant to only R or with combination of other drugs except H (R+) and remaining 6 (13%) were resistant at least HR. No changes in the regimen were made according to the results of the resistance tests. The conversion rate of sputum smear / culture occured within first and second months were 47% / 35% and 84% / 86% respectively. The outcomes were analysed in five cathegories. Of the patients , 14 (28%) were cured, 17 (34%) completed and 14 (28%) abandoned their treatment, 1 (2%) failed and 4 (8%) died. Favorable results were obtained in 31 (97%) patients who completed the treatment. There was no statistical difference between two groups according to the conversion rates and treatment results. In conclusion, the standart WHO re-treatment regimen given under direct observation regardless of drug susceptibility test results will further enhance the success rate of the treatment. However, longer periods of follow-up is warranted in order to establish final conclusion.

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Citations should be made in the following way:
M. Bilgin, A. Komurcuoglu, S. Aktogu, O. Erer, G. Tibet (Izmir, Turkey). Retreatment cases of tuberculosis. Eur Respir J 2001; 16: Suppl. 31, 3469

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