Source: Annual Congress 2001 - Immune deficiencies and the lung in childhood
Disease area: Paediatric lung diseases

Abstract

About 10% of pre-school children have RRIs which are related to environmental and/or immunological factors such as the phagocytosis (PG) and superoxide production (SP) deficiencies.
The aim of our study was to evaluate the impact of PG and SP anomalies on RRIs by the measurement of PG (FAG test) and SP (ROI test) of neutrophils (PMNs).
Serum immunoglobulins (Ig), IgG subclasses (IgG sbc), lymphocytic subpopulations (LS), FAG and ROI test were measured in 90 children with RRIs, in a moment of well being and off all medications for at least 2 weeks. FAG and ROI test were also measured in 19 healthly children.
A significant difference (p 0,0039) was found between FAG of the patients (mean 91,37) and controls (mean 95,35) as well as (p 0,0004) between ROI of the patients (mean 81,82) and controls (mean 95,17). FAG and ROI tests were normal in all 19 controls. No significant difference was found between the mean values of FAG and ROI test in 2 groups (< and > 6 yrs) of patients. A significant decreased likelyhood (OR 0,299; CI 0,072-0,968) of finding abnormal ROI in the patients with low IgA was tested by the correlation of FAG and ROI test with Ig, IgG sbc and LS; no other significant differences were found.
In conclusion, an etiological role of PG and SP deficiencies of PMNs can be supposed in the genesis of paediatric RRIs, irrespective of the age of the patients, on the contrary of literature notifications.

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Citations should be made in the following way:
V. Gregorutti, M. Canciani, M. Don, F. Pisa, F. De Franco (Udine, Italy). Recurrent respiratory infections (RRIs) and phagocytosis in childhood. Eur Respir J 2001; 16: Suppl. 31, 3434

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