Source: Annual Congress 2001 - Interstitial lung disease: BAL in diagnosis and management
Disease area: Interstitial lung diseases

Abstract

Induced sputum cell counts provide a relatively noninvasive method to evaluate the presence, type and degree of inflammation in the airways of the lung.
We compared the cell counts in BAL and induced sputum (IS) in newly diagnosed adult patients with interstitial lung disease (ILD n=18): extrinsic allergic alveolitis (EAA n=4), sarcoidosis (n=5) and idiopathic pulmonary fibrosis (IPF n=9). None had asthma or infection of upper airways. IS was gained four days after BAL by inhaling a 4% NaCL solution for 4 periods of 5 minutes. The expectorate was processed within 2 h. IS was treated with Dithiothreitol, filtered and examined in a hemocytometer for total cell count and viability. Cytospin was used for differential cell count.
There were no correlations between proportions or concentrations of lymphocytes, eosinophils and macrophages in BAL and IS. This strongly suggests that the cells sampled by the techniques of BAL are derived from different compartments. IS is likely not able to replace BAL in the diagnostic assesment of ILD.

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Citations should be made in the following way:
C. Lange, P. C. Bauer, N. Satake, J. Guzman, U. Costabel (Essen, Bochum, Germany). Lack of correlation between BAL and induced sputum cell counts. Eur Respir J 2001; 16: Suppl. 31, 3421

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