Source: Annual Congress 2001 - Markers of obstructive lung disease
Disease area: Airway diseases

Abstract

Objective. To study the association between histamine bronchial responsiveness (Yan method) and Pi phenotypes of antiprotease α₁-antitrypsin (α₁-AT) in 1807 male rurals, aged 18.6±]2.0 years, mean±]SD.
Method. Histamine chloride was given up to a dose of 1.43 mg. and log dose slope (LDS) was calculated as: log10((FEV_1start - FEV_1end) * 100/ (FEV_1start * dose) + 1). In subjects with α₁-AT serum concentration [lte] 22 μM phenotypes was tested and subjects with higher concentration were classified as MM_conc. Phenotyping was performed by means of isoelectric focusing. The different Pi-groups were collapsed into three: MM: MM_conc, MM and MX; MZS: MS and MZ, and SZ: SZ, ZZ and SS. The X represent any other allelic type.
Results. The LDS (mean±]SD) was 0.72±]0.49 for the 1621 subjects with MM Pi-group. The LDS was 0.78±]0.44 for the 177 subjects with Pi-group MZS and the LDS was 1.04±]0.82 for the 9 subjects with Pi-group SZ (linear regression: Β 0.081 (0.032), p=0.01).
Conclusion. LDS(FEV₁) of histamine responsiveness was associated to Pi-phenotypes of α₁-AT. Subjects with rare alleles seems to be the most responsive.

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T. Sigsgaard, O. Omland, O. F. Pedersen, M. R. Miller (Århus, Denmark; Birmingham, United Kingdom). Pi phenotypes of antiprotease α₁-antitrypsin and log dose slope of histamine responsiveness. Eur Respir J 2001; 16: Suppl. 31, 3413

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