Source: Annual Congress 2001 - Markers of obstructive lung disease
Disease area: Airway diseases

Abstract

Pulmonary function is dependent not only on smoking, but also on nutritional status. The red cell distribution width (RDW) is dependent on smoking and nutritional factors. To test the hypothesis that there is a relation between RDW and pulmonary function, we conducted a cross sectional study in 1616 subjects, between 35 and 79 years old, free of respiratory disease randomly selected from the local population. Pulmonary function was assessed from forced expired volume in one second (FEV1) and forced vital capacity (FVC) expressed as a percentage of predicted normal adjusted for age, height, gender and ethnicity. Log RDW was dependent on total pack years of smoking and ethnicity, but not on gender and lifetime alcohol consumption. Multiple linear regression showed that FEV1 and FVC were dependent on RDW even when total pack years, current smoking status, eosinophil count, education, weight, blood levels of vitamin C, retinol, beta-cryptoxanthin, and vitamin E were taken into account. The relation between FEV1 and FVC with RDW was present even in subjects who never smoked. Thus, RDW remains a significant covariate of FEV1 and FVC even when smoking and known important nutrient blood levels are taken into account. We suggest that RDW may be a surrogate variable for as yet unidentified nutrients that affect pulmonary function, or may be a measure of biological susceptibility of smoking and/or nutritional status.

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B. J. B. Grant, D. P. Kudalkar, P. Muti, S. E. McCann, M. Trevisan, J. L. Freudenheim, H. J. Schunemann (Buffalo, United States Of America). Association between pulmonary function and red cell distribution width in a population-based study. Eur Respir J 2001; 16: Suppl. 31, 3411

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