Prospective study of body mass index and risk of adult-onset asthma or chronic obstructive pulmonary disease in women C. A. Camargo Jr, R. G. Barr, F. E. Speizer (Boston, United States Of America)
Source: Annual Congress 2001 - Markers of obstructive lung disease
Session: Markers of obstructive lung disease Session type: Oral PresentationNumber: 3409
Disease area: Airway diseasesAbstract Recent studies have focused on the relation of obesity to asthma risk. We examined this issue for obstructive airway disease (OAD) and then for asthma and COPD separately. The Nurses' Health Study, a cohort of 121,700 female nurses, was assembled in 1976. After excluding women who died, had comorbid disease, had prevalent asthma or COPD, or incomplete risk factor data, there were 69,861 women, age 38 to 63 years, in 1984. Body mass index (BMI = weight/height2) was collected by validated questionnaire. Incident cases of asthma reported MD-diagnosis plus use of a controller medication in the preceding year; incident cases of COPD reported MD-diagnosis plus confirmatory test (PFT, radiograph or chest CT). From 1984-96, 1,677 women reported incident OAD, 719 reported incident asthma only, and 461 reported incident COPD only. Controlling for age, smoking, menopausal status, hormone use and fish oil intake, the RR of OAD for increasing categories of BMI in 1984 (ref = BMI 20.0-21.9) was RR=1.1 for BMI <20.0; 1.2 for 22.0-24.9; 1.2 for 25.0-26.9; 1.3 for 27.0-29.9; and 1.8 for >=30 (P for trend<0.001). A stronger, positive, dose-response association was observed for asthma only: RR for BMI>=30 = 2.4 ,95% CI 1.8-3.1; P trend<0.001. However, BMI in 1984 was inversely associated with COPD risk: RR for BMI >=30 = 0.6, 95% CI 0.4-0.9; P trend=0.02. In conclusion, BMI, a potentially modifiable factor, is strongly and positively associated with risk of adult-onset asthma. In contrast, higher BMI is associated with lower risk of COPD diagnosis. The increasing prevalence of obesity in developed nations may help explain concomitant increases in asthma prevalence.Rating:
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C. A. Camargo Jr, R. G. Barr, F. E. Speizer (Boston, United States Of America). Prospective study of body mass index and risk of adult-onset asthma or chronic obstructive pulmonary disease in women. Eur Respir J 2001; 16: Suppl. 31, 3409
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