Source: Annual Congress 2001 - Markers of obstructive lung disease
Disease area: Airway diseases

Abstract

Airway inflammation has an important role in the development of bronchial asthma. Previous studies have shown an increased local inflammatory activity on the airway mucus of asthma patients. However, only limited data is available, whether also systemic inflammation is associated with asthma. The aim of the present study was to analyse the association of asthma with three sensitive markers of systemic inflammation: C-reactive protein (CRP), serum amyloid-A (SAA) and plasma fibrinogen. The cross-sectional study included 1513 men aged 45-74 years, who participated in a population-based chronic disease risk factor survey in Finland in 1997.
Participants with prevalent asthma had markedly higher CRP, SAA and fibrinogen levels than participants without asthma. In logistic regression models age adjusted odds ratios (2nd, 3rd and 4th quartile as compared with 1st quartile) of asthma increased gradually with increasing quartile of CRP (1.28, 1.19, 1.96, p for trend 0.0390), SAA (1.20, 1.79, 3.49, p for trend 0.0001, and fibrinogen (1.22,1.79, 3.16, p for trend 0.0001). The associations were independent of smoking. Further adjustment for waist hip-ratio, a marker of central obesity, weakened the observed association somewhat.
In conclusion, sensitive markers of systemic inflammation, particularly SAA and fibrinogen, were positively and significantly associated with prevalent asthma. Part of the association was mediated through central obesity, which is known to be associated with the levels of inflammatory markers, and may also be associated with the risk of asthma.

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Citations should be made in the following way:
P. Jousilahti, V. Salomaa, K. Hakala, V. Rasi, E. Vahtera, T. Palosuo (Helsinki, Finland). The association of C-reactive protein, serum amyloid-A and fibrinogen with prevalent asthma. Eur Respir J 2001; 16: Suppl. 31, 3407

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