Source: Annual Congress 2001 - Markers of obstructive lung disease
Disease area: Airway diseases

Abstract

We tested whether increased concentrations of the acute phase reactant fibrinogen correlate with reduced pulmonary function, stratified by smoking status. We measured plasma fibrinogen and FEV1 in 8872 adults from the Danish general population. Smokers with plasma fibrinogen in the upper and middle tertile (>3.3 and 2.7-3.3 g/L) had FEV1 of 88% and 93% predicted compared with 94% in smokers with fibrinogen in the lower tertile (<2.7 g/L) (Mann-Whitney: P<0.001 and P=0.02). The equivalent values in nonsmokers were 97% and 101% compared with 101% (P<0.001 and P=0.90). Analysis of covariance allowing for potential confounders demonstrated that smokers in the upper and middle tertile had 166 and 59 ml less in FEV1 than smokers in the lower tertile (F statistic: P<0.001). The equivalent values for nonsmokers were 136 and 32 ml (P<0.001). We demonstrate for the first time that increased levels of plasma fibrinogen are associated with reduced lung function, and that this association is most pronounced in smokers.

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Citations should be made in the following way:
M. Dahl, A. Tybjaerg-Hansen, J. Vestbo, P. Lange, B. G. Nordestgaard (Herlev, Copenhagen, Hvidovre, Denmark). Elevated plasma fibrinogen associated with reduced pulmonary function. Eur Respir J 2001; 16: Suppl. 31, 3406

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