Source: Annual Congress 2001 - Inflammation and genetics in airway disease
Disease area: Airway diseases

Abstract

The aim of the study: investigation of features of allele polymorphism of the Glutation-S-Transferase M1 and T1 genes (GSTM1, GSTT1) in patients with bronchial asthma (BA) within the population of the North-Western region of Russia.
Material and methods: Frequencies of zero-alleles (0-allele) of GSTM1 and GSTT1 genes were studied by the method of Polymerase chain reaction (PCR) in 39 BA patients (atopic, moderate severity) and 45 healthy blood donors.
Results: It was established that the frequency of homozygotes in the gene deletion GSTM1(0/0) in general population was significantly lower (37.8%) than in BA patients (82.1%, χ2=16.8, p<0.001). The frequency of GSTM1 0/0, GSTT1 0/0 among BA patients was 57.9%, but in the control group it did not exceeded 4.7% (χ2=27.4, p<0.001).
Conclusion: The homozygousity of sero alleles GSTM1 and GSTT1 is the most characteristic feature of BA patients. Thus, mutations in both GST genes leading to decreased activity of respective enzymes could be considered as the factor of genetic risk for the development of atopic bronchial asthma.

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Citations should be made in the following way:
T. E. Gembitskaya, M. A. Petrova, T. E. Ivaschenko, O. Sideleva (Saint-Petersburg, Russia). The role of genes coding Glutation-S-Transferase M1 and T1 as risk factors for the development of bronchial asthma. Eur Respir J 2001; 16: Suppl. 31, 3388

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