Sustained alveolar hypoxia provokes biphasic vasoconstriction and loss of post-hypoxic vasorelaxation in isolated rabbit lungs

N. Weissmann, S. Winterhalder, R. Voswinckel, M. Nollen, K. Quanz, R. T. Schermuly, H. A. Ghofrani, W. Seeger, F. Grimminger (Giessen, Germany)

Source: Annual Congress 2001 - Pulmonary hypertension (miscellanea)
Session: Pulmonary hypertension (miscellanea)
Session type: Thematic Poster Session
Number: 2806
Disease area: Pulmonary vascular diseases, Respiratory critical care

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
N. Weissmann, S. Winterhalder, R. Voswinckel, M. Nollen, K. Quanz, R. T. Schermuly, H. A. Ghofrani, W. Seeger, F. Grimminger (Giessen, Germany). Sustained alveolar hypoxia provokes biphasic vasoconstriction and loss of post-hypoxic vasorelaxation in isolated rabbit lungs. Eur Respir J 2001; 16: Suppl. 31, 2806

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The role of superoxide in hypoxic pulmonary vasoconstriction in chronically hypoxic rat lungs
Source: Eur Respir J 2004; 24: Suppl. 48, 95s
Year: 2004

Paraquat-induced lung injury in rat presents altered pressor chemoreflex response probably due to vascular dysfunction
Source: Annual Congress 2007 - Recent advances in the understanding of lung injury and repair
Year: 2007


Genistein rescues pulmonary hypertension and attenuates abnormal vasoconstriction in rats lungs
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012

Dag-dependent regulation of trpc6 in hypoxic pulmonary vasoconstriction
Source: Annual Congress 2009 - Pathobiology of pulmonary vascular diseases
Year: 2009


Acute increase in pulmonary blood flow elevates airway responsiveness in isolated perfused rat lungs
Source: Annual Congress 2008 - Respiratory pathophysiology from cell and animal research
Year: 2008



Inhaled budesonide causes rapid vasoconstriction in the isolated and perfused rat lung
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD
Year: 2008

Hypoxia causes permeability oedema in the constant-pressure perfused rat lung
Source: Eur Respir J 2006; 27: 600-606
Year: 2006



Features of hypoxic pulmonary vasoconstriction in isolated perfused and ventilated mice lungs
Source: Eur Respir J 2003; 22: Suppl. 45, 270s
Year: 2003

Hypoxia aggravates  failure of autoresuscitation  in a rat model of LPS-induced endotoxemia.
Source: International Congress 2018 – Preclinical and clinical studies of critical illness
Year: 2018

Effects of Sildenafil on hypoxic pulmonary vasoconstriction in dogs
Source: Eur Respir J 2001; 18: Suppl. 33, 490s
Year: 2001

Redox state of mitochondrial cytochromes in isolated lungs and pulmonary arterial smooth muscle cells during acute and prolonged hypoxia
Source: Annual Congress 2007 - Cellular and molecular aspects of pulmonary hypertension
Year: 2007


Effect of induced hypothermia on alveolar macrophage function in endotoxin-challenged rats
Source: Eur Respir J 2002; 20: Suppl. 38, 485s
Year: 2002

Heparin decreases permeability of microvascular endothelium in rats with hypobaric and hypertension-induced chronic hypoxia
Source: Eur Respir J 2002; 20: Suppl. 38, 89s
Year: 2002

Dexamethasone induces anti-remodelling effects in rat pulmonary arterial smooth muscle cells
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and cell biology
Year: 2012


Hypoxia impairs β2 adrenergic signalling and stimulation of alveolar reabsorption in rat alveolar epithelial cells
Source: Annual Congress 2009 - Highlighting the epithelial cell in lung disease: from COPD to cancer to acute lung injury
Year: 2009


Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in the mouse
Source: Annual Congress 2006 - Taormina 4th ERS Lung Science Conference "hypoxia in lung biology and disease"
Year: 2006


Influence of depletion of alveolar macrophages by 2-chloroadenosine inhalation on apoptosis in candida-induced acute lung injury
Source: Eur Respir J 2002; 20: Suppl. 38, 488s
Year: 2002

Co-culturing alveolar epithelial with lung micro-vascular endothelial cells attenuates hypoxia-induced alveolar leakage and inhibition of reabsorption
Source: Annual Congress 2009 - Crossing the line: alveolo-capillary barrier control in acute lung injury
Year: 2009

Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction
Source: Eur Respir J 2010; 36: 323
Year: 2010