Anti-fibrotic effects of pirfenidone on pulmonary arterial vascular smooth muscle cells

Changwu Lu (Giessen, Germany), Changwu Lu, Tatyana Novoyatleva, Baktybek Kojonazarov, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Norbert Weissmann, Werner Seeger, Ralph Schermuly

Source: International Congress 2016 – The nature of pulmonary hypertension
Session: The nature of pulmonary hypertension
Session type: Poster Discussion
Number: 5091
Disease area: Interstitial lung diseases, Pulmonary vascular diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Changwu Lu (Giessen, Germany), Changwu Lu, Tatyana Novoyatleva, Baktybek Kojonazarov, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Norbert Weissmann, Werner Seeger, Ralph Schermuly. Anti-fibrotic effects of pirfenidone on pulmonary arterial vascular smooth muscle cells. Eur Respir J 2016; 48: Suppl. 60, 5091

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Comparison of current therapies against endothelin-induced growth in pulmonary smooth arterial muscle cells (PASMCs) derived from patients with pulmonary arterial hypertension
Source: International Congress 2014 – Pulmonary hypertension: novel targets and drugs
Year: 2014


Increased Cyr61 in pulmonary arterial hypertension involving in proliferation of pulmonary arterial smooth muscle cells
Source: International Congress 2016 – Pulmonary hypertension and pulmonary embolism: from the bench to the bedside
Year: 2016


Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats
Source: Eur Respir J 2011; 37: 1104-1118
Year: 2011



IL-6 receptor overexpression in pulmonary arterial smooth muscle cells in idiopathic pulmonary hypertension
Source: International Congress 2015 – Pulmonary hypertension: novel insights into the biology of the disease
Year: 2015

Antiproliferative effects of drugs affecting different signalling pathways on rat and human pulmonary artery smooth muscle cells
Source: International Congress 2015 – Pulmonary hypertension: rare and hereditary causes of PAH
Year: 2015

SMAD3 regulation contributes to lung vascular remodeling in pulmonary arterial hypertension
Source: International Congress 2015 – Respiratory translational research: novel mechanisms, diagnostic markers and Space Odyssey
Year: 2015



Smooth muscle microparticles as novel biomarkers of vascular remodelling and inflammation in pulmonary arterial hypertension
Source: International Congress 2014 – Pulmonary hypertension: novel targets and drugs
Year: 2014

Nuclear factor-kappa B inhibition exerts anti-remodelling effects in pulmonary arterial smooth muscle cells
Source: International Congress 2014 – Pathobiology of pulmonary hypertension
Year: 2014

Uric acid causes excessive pulmonary arterial smooth muscle cell proliferation via URATv1 upregulation in pulmonary arterial hypertension
Source: International Congress 2016 – The nature of pulmonary hypertension
Year: 2016

Imatinib lowers the pulmonary vascular tone in human and guinea pig lung tissue
Source: Annual Congress 2013 –Pulmonary circulation: animal models and experimental treatments
Year: 2013

Anti-contractile and anti-proliferative responses in human pulmonary arterial smooth muscle cells induced by ACT-333679, the active metabolite of selexipag, a non-prostanoid selective prostacyclin receptor agonist
Source: International Congress 2014 – Pulmonary hypertension: novel targets and drugs
Year: 2014

Pulmonary hypertension: the science behind the disease spectrum
Source: Eur Respir Rev 2012; 21: 19-26
Year: 2012



Analysis of pulmonary endothelial microparticles, haemodynamics and functional class in pulmonary hypertension
Source: International Congress 2015 – Pulmonary hypertension: novel insights into the biology of the disease
Year: 2015

Obligatory role of MEK/ERK/RSK90 in the mitogenic responses of human pulmonary artery smooth muscle cells
Source: International Congress 2014 – Pulmonary hypertension: pathobiology
Year: 2014

MIF/CD74 contributes to the endothelial pro-inflammatory phenotype in pulmonary arterial hypertension
Source: Annual Congress 2013 –Pulmonary circulation: basic science
Year: 2013

PDGF promotes pulmonary artery smooth muscle cell proliferation and migration in pulmonary arterial hypertension
Source: Annual Congress 2006 - Signalisation in the pulmonary vasculature: new pathways and wrong signals
Year: 2006


Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition
Source: Eur Respir J 2008; 31: 599-610
Year: 2008



NMDA receptor crosstalk with PDGFR-β and BMPR2 is involved in smooth muscle cell proliferation in pulmonary arterial hypertension
Source: International Congress 2016 – The nature of pulmonary hypertension
Year: 2016

Endothelial-derived MIF contributes to pulmonary endothelial cell proliferation in human pulmonary arterial hypertension
Source: International Congress 2015 – Pulmonary hypertension: promising small molecules
Year: 2015

The effect of ASK1 inhibition on hypoxia-induced pulmonary artery fibroblast activation and associated paracrine effects on vascular smooth muscle cells
Source: International Congress 2016 – The nature of pulmonary hypertension
Year: 2016