Source: International Congress 2016 – Important factors, besides smoking, that relate to lung function and decline in lung function
Disease area: Airway diseases

Abstract

Background: Several studies have reported pulmonary function (PF) impairment associated to abdominal fat deposition; most of them have used waist circumference as the measure of abdominal fat deposition. Few studies use techniques that can distinguish visceral from subcutaneous adipose tissue.Objectives: To measure the association between visceral and subcutaneous adiposity and PF.Methods: The analyses were conducted in the 30 years old data from the 1982 Pelotas (Brazil) birth cohort study. 1,701 men and 1,712 women underwent spirometry and abdominal ultrasound measures. The visceral fat thickness was defined as the distance on the sagittal plane from the peritoneum to the lumbar spine and the subcutaneous fat thickness the distance between the skin and the linea alba (centimeters); linear regressions were stratified by sex and adjusted by height, weight, skin color, self-reported wheezing, smoking status, physical activity, corticoids, socioeconomic and perinatal variables.Results: None of the subcutaneous measures were associated with FEV₁ or FVC, while visceral fat was consistent inversely linear associated to both. To each centimeter of visceral fat FEV₁ was -71ml (95%CI -89; -54) and FVC: -85ml (95%CI -105; -64) in males; in females, FEV₁ was -66ml (95%CI -80; -52) and FVC -71ml (95%CI -87; -55); p-values <0.001.Conclusions: Visceral adipose tissue plays an important role when assessing possible restrictive PF disorders caused by upper body excess of fat.


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Ana Maria Menezes (Pelotas, Brazil), Ana Maria Menezes, Paula D. de Oliveira, Fernando C. Wehrmeister, Rogelio Pérez-Padilla, Helen Gonçalves, Maria Cecília F. Assunção, Bernardo L. Horta, Denise P. Gigante, Fernando C. Barros. Abdominal adiposity measured by ultrasound and pulmonary function: A cross-sectional analysis nested in a birth cohort. Eur Respir J 2016; 48: Suppl. 60, 5000

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