Source: International Congress 2016 – Important factors, besides smoking, that relate to lung function and decline in lung function
Disease area: Airway diseases

Abstract

Comorbidities are common among subjects with COPD, and most probably contribute to the increased mortality observed among subjects with COPD. The association between different comorbidities and mortality is rarely studied.Aim: To evaluate the impact of common comorbidities; heart disease (HD), diabetes mellitus (DM) and anxiety/depression (A/D), on mortality in a population based study of subject with and without airway obstruction.Methods: The OLIN COPD study was recruited from population based studies in 2002-04 including spirometry and structured interview. All 993 subjects with airway obstruction, FEV₁/(F)VC<0.70, were identified together with age- and sex matched referents without airway obstruction. Mortality data was collected until December 2015.Results: The cumulative mortality was significantly higher among subjects with than without airway obstruction, 37.9% vs. 29.2% (p<0.001). In a multivariate model, airway obstruction increased the risk for death also when adjusted for age, sex and smoking habits, HR 1.21 (95%CI 1.03-1.43). HD, DM and A/D were analysed as risk factors for death, HR (95%CI), in a model adjusting for sex, age and smoking habits; among subjects with airway obstruction 1.19(0.91–1.56), 1.51(1.10– 2.08) and 1.45(1.04– 2.02), and among non-obstructive 1.32(1.05–1.67), 1.40(1.04-1.87) and 1.38 (1.08–1.77).Conclusion: Heart disease, diabetes mellitus and anxiety/depression increased the risk for death independently of each other both among subjects with and without airway obstruction, even though heart disease did not reach significance as a risk factor for death among those with airway obstruction.


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Sami Sawalha (Boden, Sweden), Sami Sawalha, Linnea Hedma, Helena Backman, Eva Rönmark, Bo Lundbäck, Anne Lindberg. LATE-BREAKING ABSTRACT: The impact of comorbidities on all-cause mortality among subjects with and without airway obstruction. Eur Respir J 2016; 48: Suppl. 60, 4997

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