A common intragenic marker of cysteinyl leukotrienes receptor-1 (T927C) does not correlate with a clinical response to the receptor's antagonist but is associated with peripheral blood eosinophilia

M. Sanak, V. Martin, L. Mastalerz, C. D. Funk, A. Szczeklik (Cracow, Poland; Philadelphia, United States Of America)

Source: Annual Congress 2001 - Leukotriene receptor antagonists in clinical practice
Session: Leukotriene receptor antagonists in clinical practice
Session type: Thematic Poster Session
Number: 1766
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Sanak, V. Martin, L. Mastalerz, C. D. Funk, A. Szczeklik (Cracow, Poland; Philadelphia, United States Of America). A common intragenic marker of cysteinyl leukotrienes receptor-1 (T927C) does not correlate with a clinical response to the receptor's antagonist but is associated with peripheral blood eosinophilia. Eur Respir J 2001; 16: Suppl. 31, 1766

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Serotonin (5-hydroxytryptamine) modulates cytokine and chemokine production in lipopolysaccharide-primed human monocytes via stimulation of different 5-HT receptor subtypes
Source: Annual Congress 2005 - Inflammation and remodelling in allergy and asthma
Year: 2005


Cysteinyl leukotriene receptor antagonist regulates vascular permeability by reducing VEGF expression
Source: Eur Respir J 2004; 24: Suppl. 48, 129s
Year: 2004

Cysteinyl leukotriene receptor 1 gene variation and risk of asthma
Source: Eur Respir J 2009; 33: 42-48
Year: 2009



Leukotriene C4 synthase polymorphism does not associate with clinical response to leukotriene receptor antagonists in persistent asthma
Source: Eur Respir J 2002; 20: Suppl. 38, 303s
Year: 2002

Homozygosity for the FCER2 gene is associated with an increased use of leukotriene receptor antagonists
Source: International Congress 2017 – Insight into childhood asthma and paediatric pulmonology
Year: 2017


A novel receptor antagonist, c-027, inhibits airway contraction in human and murine models of allergen, independent of inflammatory mediator release
Source: Annual Congress 2009 - Novel mechanisms in the pathogenesis of asthma
Year: 2009

GB001, a selective prostaglandin D2 receptor 2 antagonist, blocks signaling in the peripheral blood of healthy subjects
Source: Virtual Congress 2020 – Clinical and laboratory pharmacology in asthma
Year: 2020


Increased expression of ADRB2, CHRM3 and glucocorticoid alpha receptor genes in blood leukocytes of COPD patients
Source: International Congress 2016 – Airway pharmacology: drug targets and mode of action
Year: 2016


Expression of cysteinyl leukotriene 1 receptor in peripheral blood stem cell-derived human basophils
Source: Eur Respir J 2006; 28: Suppl. 50, 856s
Year: 2006

The pro-apoptotic effect of cysteinyl leukotriene receptor (CysLT-R) antagonist montelukast is mediated by CysLT-Rs expression on antigen-stimulated T cells
Source: Eur Respir J 2003; 22: Suppl. 45, 100s
Year: 2003

Enhanced platelet activating factor receptor (PAFR) expression in smoker airways
Source: Annual Congress 2011 - Insight into mechanisms of respiratory infections
Year: 2011


Selective versus non-selective endothelin receptor antagonists
Source: Annual Congress 2005 - New treatments in pulmonary hypertension
Year: 2005

Effect of leukotriene receptor antagonist on expression and variation of TGF-beta in T lymphocyte for mild persistent asthma in children
Source: Annual Congress 2011 - Treating childhood asthma
Year: 2011


Endothelin receptor antagonists (ERAs) neutralize LPS-induced cytokine release from pulmonary vascular smooth muscle cells (PVSMCs) by down-regulation of CD14
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Promoter polymorphisms of cysteinyl leukotriene type 1 receptor in patients with severe asthma
Source: Annual Congress 2007 - Novel therapeutic targets and disease markers in pulmonary pathology
Year: 2007



The effects of a cysteinyl leukotriene receptor antagonist, pranlukast, on dendritic cell chemoattractants in the airways of subjects with asthma
Source: Eur Respir J 2004; 24: Suppl. 48, 132s
Year: 2004

Inhibition of eosinophil migration by montelukast, a cysteinyl leukotriene receptor antagonist, through down regulation of plasmin activity
Source: Eur Respir J 2004; 24: Suppl. 48, 36s
Year: 2004

A leukotriene antagonist, montelukast, reduces in vitro LTD4 increases in peripheral blood eosinophil progenitor colonies in atopic subjects
Source: Eur Respir J 2001; 18: Suppl. 33, 531s
Year: 2001

Muscarinic receptors, leukotriene B4 production and neutrophilic inflammation in COPD patients
Source: Eur Respir J 2004; 24: Suppl. 48, 20s
Year: 2004

Expression on peripheral blood (PB) and induced sputum (IS) neutrophils (N) of the IL-8 receptors CXCR1 and CXCR2. Comparison between neutrophilic asthma and COPD
Source: Annual Congress 2003 - From gene to breath analysis in airway disorders
Year: 2003