Inhalation of α 1-protease inhibitor (α 1-Pi): influence on the protease-antiprotease balance in the epithelial lining fluid (ELF) of patients with α 1-Pi deficiency

M. Wencker, C. Vogelmeier, M. Maas-Enriquez, H. Beckmann, N. Konietzko (Essen, Munich, Leverkusen, Germany)

Source: Annual Congress 2001 - Mechanisms of airway inflammation in asthma and COPD
Session: Mechanisms of airway inflammation in asthma and COPD
Session type: Thematic Poster Session
Number: 1702
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Wencker, C. Vogelmeier, M. Maas-Enriquez, H. Beckmann, N. Konietzko (Essen, Munich, Leverkusen, Germany). Inhalation of α 1-protease inhibitor (α 1-Pi): influence on the protease-antiprotease balance in the epithelial lining fluid (ELF) of patients with α 1-Pi deficiency. Eur Respir J 2001; 16: Suppl. 31, 1702

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
A phase 1B/2A study to evaluate the effect of aerosolized, recombinant alpha 1-antitrypsin (rAAT) on epithelial lining fluid (ELF) analytes in subjects with AAT deficiency
Source: Eur Respir J 2005; 26: Suppl. 49, 287s
Year: 2005

Inhibition of elastinolytic activity in induced sputum from COPD patients and healthy controls by recombinant alpha 1-antitrypsin (rAAT) and a fusion protein, TAPI
Source: Eur Respir J 2004; 24: Suppl. 48, 471s
Year: 2004

Alpha 1-Antitrypsin deficiency (AATD) in patients with ARDS consequent to SARS-CoV-2 infection.
Source: Virtual Congress 2021 – COVID – 19: treatments and predictive factors
Year: 2021


Intra-epithelial polymerization, accumulation and secretion of alpha1 antitrypsin (AAT) Z polymers in the lung of patients with alpha-1 antitrypsin deficiency (AATD)
Source: Annual Congress 2010 - Epithelial cell biology
Year: 2010



Alpha 1 antitrypsin (A1AT) deficiency among patients with cystic fibrosis
Source: Eur Respir J 2003; 22: Suppl. 45, 501s
Year: 2003

Phase I safety investigation of an aerosolized, recombinant alpha 1-antitrypsin in subjects with alpha 1-antitrypsin deficiency
Source: Eur Respir J 2004; 24: Suppl. 48, 228s
Year: 2004

Reduction in incidence of exacerbations in patients with alpha 1 antitrypsin deficiency (A1ATD) treated with concentrates of alpha 1 antitrypsin (A1AT): REXA study
Source: Annual Congress 2011 - Biomarkers and exacerbations of asthma and COPD
Year: 2011


Alveolar nitric oxide correlates with lung volumes in patients with emphysema and Alpha-1 antitrypsin deficiency (AATD)
Source: Eur Respir J 2006; 28: Suppl. 50, 223s
Year: 2006

Inhaled recombinant alpha 1-antitrypsin ameliorates cigarette-induced lung damage in the smoking mouse model
Source: Annual Congress 2004 - Insights into asthma and COPD
Year: 2004


Immune activation in α1 antitrypsin deficiency (AATD) emphysema: Beyond the protease/antiprotease hypothesis
Source: Annual Congress 2012 - Mechanistic studies in airway cell biology
Year: 2012

Estimated numbers and prevalence of PI*S and PI*Z deficiency alleles of α1-antitrypsin deficiency in Asia
Source: Eur Respir J 2006; 28: 1091-1099
Year: 2006



Neutrophil elastase gene expression and relation with lung function in Alpha-1 Antitrypsin deficiency patients.
Source: International Congress 2017 – Current molecular and genetic understanding of lung diseases
Year: 2017

Variability of sputum inflammatory mediators in COPD and ?1-antitrypsin deficiency},
Source: Eur Respir J 2012; 40: 561-569
Year: 2012



Effect of recombinant α-1 antitrypsin (rAAT) and TAPI on neutrophil elastase (NE) and matrix metalloproteinase-9 (MMP9) activity in induced sputum (IS) from healthy smokers and patients with chronic obstructive pulmonary disease (COPD)
Source: Annual Congress 2003 - Progress on therapy for chronic obstructive pulmonary disease
Year: 2003


Lung function in relation to emphysema development in alpha-1 antitrypsin deficiency
Source: International Congress 2019 – Insights into physiological diagnostic services
Year: 2019


Alpha 1-antitrypsin deficiency
Source: Breathe 2008; 4: 377-380
Year: 2008

α1-Antitrypsin inhalation reduces airway inflammation in cystic fibrosis patients
Source: Eur Respir J 2007; 29: 240-250
Year: 2007



Ventilation inhomogeneity is correlated with biomarkers of parenchymal destruction in alpha1 antitrypsin deficiency
Source: Eur Respir J 2007; 30: Suppl. 51, 620s
Year: 2007

Alpha-1 antitrypsin genotypes and associated inhibitory activity towards neutrophil serine proteinases, in vivo
Source: International Congress 2015 – Translational research in respiratory care: new findings
Year: 2015

Lung deposition of inhaled alpha1-proteinase inhibitor in cystic fibrosis and alpha1-antitrypsin deficiency
Source: Eur Respir J 2009; 33: 354-360
Year: 2009