Source: International Congress 2016 – Treatment options for obstructive sleep apnoea and obesity hypoventilation
Disease area: Sleep and breathing disorders

Abstract

Background: There is limited data concerning long-term effects of positive airway pressure (PAP) therapy on survival and functional status in patients with obesity hypoventilation syndrome (OHS).Aims: To assess the role of different levels of compliance and long-term effects of PAP therapy on gas exchange, sleepiness, quality of life, depression and death rate in patients with OHS.Methods: Two hundred fifty two OHS patients, newly diagnosed, who have been recommended PAP therapy, were followed up for a minimum of 2 years. Arterial blood samples were taken for gas level measurements with patients awake, for more than 4 h since wakening.The hours/day and percentage of days PAP was used were monitored. Epworth sleepiness scale (ESS), quality of life (Short Form 36-SF-36) and Beck Depression Inventory (BDI) were recorded together with the death rate before and at the end of the follow up period.Results: At the end of thefollow-up period (mean duration, 50 months), PaO₂ had increased from baseline (p<0.001), and both PaCO₂ and HCO₃^-had decreased (p<0.001). PAP therapy also significantly improved ESS (p<0.001), BDI (p<0.001) and SF-36(p<0.001) scores. During follow-up, 11 patients died (2 due to progressionof respiratory failure). Patients who used PAP therapy for > 6 hours/day had a considerably greater improvement in blood gases and questionnaires scores than less adherent patients.Conclusions: Increased hours of use and long-term therapy with PAP are effective in the treatment of patients with OHS. Clinicians should encourage adherence to PAP therapy in order to provide a significant improvement in clinical status and gas exchange in these patients.


Rating:

Share or cite this content

Citations should be made in the following way:
Izolde Bouloukaki (Crete, Greece), Izolde Bouloukaki, Charalampos Mermigkis, Charalampos Protopapadakis, Nikolaos Tzanakis, Stylianos Michelakis, Eleni Mauroudi, Violeta Moniaki, Dimitrios Georgopoulos, Sophia Schiza. Long term effects of compliance with positive airway pressure (PAP) therapy in patients with obesity hypoventilation syndrome (OHS). Eur Respir J 2016; 48: Suppl. 60, 3427

Member's Comments

No comment yet.

Related content which might interest you: LATE-BREAKING ABSTRACT: Heart rate variability (HRV) in patients with severe obstructive sleep apnea syndrome (OSA) and its response to a 3-month continuous positive airway pressure (CPAP) therapy Source: International Congress 2014 – Sleep disordered breathing 4 Year: 2014 The effect of CPAP on blood pressure in patients with OSAS and resistant hypertension followed 1 year Source: International Congress 2015 – Inflammation, biomarkers and hypoxia in sleep disordered breathing Year: 2015 Adherence to continuous positive airway pressure therapy (CPAP) in patients with obstructive sleep apnea (OSA) in an Asian privately funded healthcare system Source: International Congress 2014 – Sleep disordered breathing 3 Year: 2014 Study of factors affecting compliance of continuous positive airway pressure (CPAP) in obstructive sleep apnea-hypopnea syndrome (OSAHS) Source: International Congress 2016 – Technical aspects, compliance, and adherence to positive airway pressure in sleep apnoea Year: 2016 Influence of nasal mask choice for continuous positive airway pressure (CPAP) therapy in patients with obstructive sleep apnoea (OSA) Source: International Congress 2014 – The technical and diagnostic agenda in OSA Year: 2014 Continuous positive airway pressure therapy for obstructive sleep apnoea: Do patients who request to have a copy of their letters have better compliance? Source: International Congress 2015 – To treat or not to treat, and how? Sleep-disordered breathing I Year: 2015 Effect of continuous positive airway pressure on blood pressure and the metabolic profile of women with obstructive sleep apnoea. A randomized-controlled trial Source: International Congress 2016 – Cardiovascular and metabolic pathophysiology and outcomes of obstructive sleep apnoea Year: 2016 Oscillating positive airway pressure (O-PAP) vs CPAP treatment in patients with obstructive sleep apneas Source: International Congress 2014 – The technical and diagnostic agenda in OSA Year: 2014 The role of compliance with positive airway pressure use on blood pressure in patients with obstructive sleep apnea: Is longer use a key-factor? Source: International Congress 2015 – Paediatric and adult sleep-disordered breathing: from inflammation to treatment and telemedicine Year: 2015 The positive effect of CPAP therapy on the level of liver enzymes in obstructive sleep apnea patients Source: International Congress 2015 – Inflammation, biomarkers and hypoxia in sleep disordered breathing Year: 2015 Tri-level ventilation versus CPAP treatment in treatment of complex sleep apnoea syndrome Source: International Congress 2015 – To treat or not to treat? Sleep-disordered breathing II Year: 2015 Weight changes in patients with obstructive sleep apnoea syndrome (OSAS) before and after CPAP Source: International Congress 2014 – Sleep disordered breathing: from children to the elderly Year: 2014 Factors determining continuous positive airway pressure (CPAP) compliance in obstructive sleep apnea (OSA) Source: International Congress 2015 – To treat or not to treat, and how? Sleep-disordered breathing I Year: 2015 Impact of a custom-made mandibular repositioning device (MRD) on blood pressure (BP) in obstructive sleep apnea (OSA) patients noncompliant with continuous positive airway pressure (CPAP) Source: International Congress 2015 – To treat or not to treat? Sleep-disordered breathing II Year: 2015 Transition from obstructive sleep apnea (OSA) to obesity hypoventilation syndrome (OHS) Source: International Congress 2015 – Measuring sleep-disordered breathing in children and adults I: questionnaires, epidemiology and sleep studies Year: 2015 Cognitive function was improved after continuous positive airway pressure treatment in obstructive sleep apnea syndrome Source: International Congress 2016 – Technical aspects, compliance, and adherence to positive airway pressure in sleep apnoea Year: 2016 Long-term evaluation of positional therapy with the sleep position trainer (SPT) in the treatment of positional obstructive sleep apnea syndrome (POSA) Source: International Congress 2014 – The technical and diagnostic agenda in OSA Year: 2014 Obstructive sleep apnea (OSA) in elderly patients. Role of continuos positive airway pressure (CPAP) treatment. A multicenter randomized controlled clinical trial Source: International Congress 2014 – Three ages of man: OSA in children, adults and the elderly Year: 2014 Resting energy expenditure among patients with obstructive sleep apnea syndrome: The impact of a single CPAP application Source: International Congress 2015 – Monitoring sleep-disordered breathing in children and adults Year: 2015 Noninvasive ventilatin efficacy for obesity hypoventilation syndrome without severe sleep apnea Source: International Congress 2016 – Epidemiological aspects of obstructive sleep apnoea Year: 2016