Source: International Congress 2016 – Treatment options for obstructive sleep apnoea and obesity hypoventilation
Disease area: Sleep and breathing disorders

Abstract

BACKGROUND:The aim of this study is to evaluate the presence of neurocognitive dysfunctions, depression and anxiety and the effect of positive airway pressure (PAP) therapy on these parameters in OHS patients.METHODS:Ten healthy normal and obese controls, 10 OHS and 10 OSAS patients were included in the study. Short form-36, Beck Depression Scale and State-Trade Anxiety Inventory (STAI 1-2) were performed. Wisconsin Card Sorting Test (WCST), Montreal Cognitive Assessment Scale (MOCA), Enhanced Cued Recall (ECR) and Mini Mental Test (MMT) were used for neurocognitive evaluation. All tests were repeated after one night PAP therapy in patient groups.RESULTS:OHS patients had the lowest scores of physical functioning (PF) and social functioning (SF) in SF-36. The total numbers of perseverative errors and incorrect answers were highest in OHS group in WCST. The scores of MOCA, ECR and MMT were lower than controls (p=0,00). Depression and anxiety scores were higher in OHS group than controls (p=0,00) while they were similar in OSAS. There was a significant increase of the number of completed categories in OHS after PAP therapy (p=0,03). Also there were significant increases of MOCA, ECR and MMT and significant decreases of depression and anxiety scores with respect to PAP therapy.CONCLUSIONS:Cognitive dysfunction, depression and anxiety are important underrecognized comorbidities in OHS. It is suggested that short-term PAP therapy had positive effects on neurocognitive functions, depression and anxiety but further multicentre, prospective studies with large number of cases are needed to evaluate the effect of long term PAP therapy on these parameters.


Rating:

Share or cite this content

Citations should be made in the following way:
Fusun Yildiz (Kocaeli, Turkey), Fusun Yildiz, Serap Argun Baris, Dilek Tuncel, Cigdem Ozerdem, Huseyin Kutlu, Tugba Onyilmaz, Ilknur Basyigit, Hasim Boyaci. The effect of positive airway pressure therapy on neurocognitive functions, depression and anxiety in obesity hypoventilation syndrome. Eur Respir J 2016; 48: Suppl. 60, 3426

Member's Comments

No comment yet.

Related content which might interest you: Cognitive function was improved after continuous positive airway pressure treatment in obstructive sleep apnea syndrome Source: International Congress 2016 – Technical aspects, compliance, and adherence to positive airway pressure in sleep apnoea Year: 2016 Obesity hypoventilation syndrome and neurocognitive function - impact of positive airway pressure therapy Source: International Congress 2018 – Sleep-disordered breathing: cardiovascular consequences, epidemiology, phenotypes and comorbidities Year: 2018 Evaluation quality of life, anxiety, and depression in patients with obstructive sleep syndrome before and after three and twelve months of continuous positive airway pressure therapy Source: Virtual Congress 2021 – Advances in therapeutic plans for sleep disordered breathing Year: 2021 The effect of continuous positive airway pressure on basal metabolism rate in patients with severe obstructive sleep apnea syndrome Source: International Congress 2015 – Ring of fire: inflammation and metabolism in sleep-disordered breathing Year: 2015 Impact of continuous positive airway pressure therapy on atrial electromechanical delay in obesity-hypoventilation syndrome patients Source: International Congress 2015 – Comorbidities in sleep-disordered breathing and sleep-disordered breathing as a comorbidity Year: 2015 Obesity-hypoventilation syndrome carries an increased risk of death over sleep apnea syndrome Source: International Congress 2014 – Home noninvasive ventilation: still a "work in progress"? Year: 2014 Long term effects of compliance with positive airway pressure (PAP) therapy in patients with obesity hypoventilation syndrome (OHS) Source: International Congress 2016 – Treatment options for obstructive sleep apnoea and obesity hypoventilation Year: 2016 Effects of continuous positive airway pressure on arterial stiffness and oxidative stress in patients with obstructive sleep apnoea Source: International Congress 2016 – New insights into noninvasive ventilation: between the dream and reality Year: 2016 Effects of 1 year of treatment with nocturnal CPAP in overlap syndrome Source: International Congress 2015 – To treat or not to treat, and how? Sleep-disordered breathing I Year: 2015 Effect of continuous positive airway pressure therapy on metabolic control in patients with morbid obesity and obstructive sleep apnoea Source: Annual Congress 2013 –Burn after reading: inflammation in sleep disordered breathing Year: 2013 Ventilatory management in COPD-associated obstructive sleep apnea syndrome Source: International Congress 2015 – Novelties in noninvasive ventilation Year: 2015 Noninvasive ventilatin efficacy for obesity hypoventilation syndrome without severe sleep apnea Source: International Congress 2016 – Epidemiological aspects of obstructive sleep apnoea Year: 2016 Factors influencing the level of efficient pressure of continuous positive airway pressure (CPAP) in the treatment of obstructive sleep apnea (OSAS) Source: International Congress 2016 – Technical aspects, compliance, and adherence to positive airway pressure in sleep apnoea Year: 2016 Efficacy of auto-trilevel positive airway ventilation on patients with both obesity hypoventilation and obstructive sleep apnea syndromes Source: Annual Congress 2013 –Twist in the tale: treating sleep disordered breathing - new technologies, new techniques Year: 2013 Blood pressure indices in patients with obstructive sleep apnea and overlap syndrome Source: International Congress 2014 – Clinical problems in acute and chronic lung diseases Year: 2014 Compliance to non-invasive continuous positive airway pressure ventilation in children with obstructive sleep apnoea Source: International Congress 2015 – Outcome of noninvasive ventilatory support in acute and chronic respiratory failure Year: 2015 Effects of continuous positive airway pressure therapy in patients with severe obstructive sleep apnea and endothelial dysfunction on 24-hour blood pressure profile Source: International Congress 2015 – Inflammation, biomarkers and hypoxia in sleep disordered breathing Year: 2015 Factors determining continuous positive airway pressure (CPAP) compliance in obstructive sleep apnea (OSA) Source: International Congress 2015 – To treat or not to treat, and how? Sleep-disordered breathing I Year: 2015 Relationship between aldosterone and the metabolic syndrome in patients with obstructive sleep apnea: Effect of continuous positive airway pressure treatment Source: Annual Congress 2013 –A metabolic medley: sleep disordered breathing Year: 2013 The role of compliance with positive airway pressure use on blood pressure in patients with obstructive sleep apnea: Is longer use a key-factor? Source: International Congress 2015 – Paediatric and adult sleep-disordered breathing: from inflammation to treatment and telemedicine Year: 2015