LATE-BREAKING ABSTRACT: Single-dose safety, tolerability, PD & PK of AZD8999, a bi-functional muscarinic antagonist/β2-agonist (MABA), in patients with COPD

Dave Singh (Manchester, United Kingdom), Dave Singh, Tim Mant, Helena Pujol, Èric Massana, Meritxell Falques, Marisa Gonzalez, Carol Astbury

Source: International Congress 2016 – Novel insights into the treatment of COPD
Session: Novel insights into the treatment of COPD
Session type: Oral Presentation
Number: 3307
Disease area: Airway diseases

Congress or journal article abstractSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Dave Singh (Manchester, United Kingdom), Dave Singh, Tim Mant, Helena Pujol, Èric Massana, Meritxell Falques, Marisa Gonzalez, Carol Astbury. LATE-BREAKING ABSTRACT: Single-dose safety, tolerability, PD & PK of AZD8999, a bi-functional muscarinic antagonist/β2-agonist (MABA), in patients with COPD. Eur Respir J 2016; 48: Suppl. 60, 3307

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Safety, pharmacodynamics (PD) and pharmacokinetics (PK) of darotropium (DARO) and vilanterol (VI) in healthy subjects: Two phase 1 studies
Source: Annual Congress 2013 –Asthma and COPD drugs: efficacy, safety and pharmacoeconomics
Year: 2013

Safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single (SD) and repeat (RD) inhaled doses of a novel phosphoinositide 3-kinase δ inhibitor (PI3Kδ), GSK2269557, administered to healthy smokers
Source: International Congress 2014 – New drugs for asthma, COPD and pulmonary fibrosis
Year: 2014


LATE-BREAKING ABSTRACT: Safety, pharmacokinetics and pharmacodynamics of BI 1060469, a novel oral CRTH2 antagonist
Source: International Congress 2016 – Asthma management
Year: 2016


Safety, pharmacokinetics (PK) and pharmacodynamics (PD) of single doses of GSK573719 inhalation powder, a new long-acting muscarinic antagonist (LAMA), in patients with COPD
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics I
Year: 2011

LATE-BREAKING ABSTRACT: Safety, pharmacokinetic and pharmacodynamic profile of RV1162, a narrow spectrum kinase inhibitor, in healthy subjects and COPD patients
Source: International Congress 2015 – Emerging strategies for airway disease treatments
Year: 2015

Effect of severe renal impairment (SRI) on umeclidinium (UMEC) and vilanterol (VI) pharmacokinetics (PK)
Source: Annual Congress 2013 –COPD drugs: new findings
Year: 2013

Effect of moderate hepatic impairment (MHI) on umeclidinium (UMEC) and vilanterol (VI) pharmacokinetics (PK)
Source: Annual Congress 2013 –Asthma and COPD management: novel clinical findings
Year: 2013

LATE-BREAKING ABSTRACT: A Phase 1b study of PUR0200, a novel tiotropium formulation, in COPD patients
Source: International Congress 2015 – Emerging strategies for airway disease treatments
Year: 2015

Pharmacokinetic (PK) analysis of fluticasone furoate (FF), umeclidinium (UMEC) and vilanterol (VI) following triple therapy in healthy subjects
Source: International Congress 2014 – Asthma and COPD management
Year: 2014


LATE-BREAKING ABSTRACT: Safety, pharmacokinetic and pharmacodynamic profile of RV568, a narrow spectrum kinase inhibitor, following repeat inhaled dosing in COPD patients
Source: Annual Congress 2013 –Hot topics on airway diseases: new horizons in treatment
Year: 2013

Safety, tolerability and pharmacokinetics of QAV680, an oral CRTh2 antagonist, in healthy subjects
Source: International Congress 2014 – Allergy and asthma: novel findings based on human cell biology
Year: 2014


Safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of GSK573719 inhalation powder in healthy subjects
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Year: 2011

Pharmacokinetics, safety and tolerability of CHF5993 a triple pMDI in renal impaired patients
Source: International Congress 2016 – Novel avenues in the treatment of COPD I
Year: 2016


Repeated-dose pharmacokinetics of once-daily TD-4208, a long-acting muscarinic receptor antagonist (LAMA), in subjects with COPD
Source: International Congress 2014 – Bronchodilators for asthma and COPD
Year: 2014


Safety, tolerability and pharmacokinetics of an oral competitive reversible CRTh2 antagonist, QAW039, in healthy subjects
Source: International Congress 2014 – Allergy and asthma: novel findings based on human cell biology
Year: 2014


Pharmacokinetic (PK) analysis of fluticasone furoate (FF), umeclidinium (UMEC) and vilanterol (VI) following triple therapy at two UMEC doses in healthy subjects
Source: International Congress 2014 – Rationale behind respiratory drug development
Year: 2014


Cardiovascular (CV) safety of aclidinium bromide/formoterol fumarate fixed dose combination (FDC) in COPD: Pooled analyses of three Phase III studies
Source: International Congress 2014 – Clinical trials of drugs and biomarkers for respiratory diseases
Year: 2014

Safety, tolerability and pharmacokinetics of CHF 6001, a novel selective inhaled PDE4 inhibitor, in healthy volunteers
Source: International Congress 2016 – Preclinical pharmacology: drug targets and mechanisms of action
Year: 2016


LATE-BREAKING ABSTRACT: TRILOGY: a phase III study to evaluate the efficacy and safety of an extrafine triple combination of beclometasone dipropionate (BDP), formoterol fumarate (FF), and glycopyrronium bromide (GB) pMDI (CHF5993) in COPD patients
Source: International Congress 2016 – Pharmacological treatment of COPD: focus on LABA/LAMA combinations
Year: 2016


Onset of action of aclidinium (ACL), glycopyrronium (GLY) and tiotropium (TIO): A comparison in COPD patients
Source: International Congress 2015 – New data on established treatments for COPD
Year: 2015