Source: Annual Congress 2001 - Monitoring acute lung disease
Disease area: Respiratory critical care

Abstract

Adult respiratory distress syndrome (ARDS) is the first and the most investigated manifestation of multiple organ failure (MOF) in shock states of different origines. Recently there are some works indicating interactions between liver function as the first protective barrier against circulating mediators (endotoxins, TNFa, interleukins, cytokines, other hemical mediators etc.) and the lung injury.
In this work we represent our observations in 65 patients with traumatic shock after multiple trauma (30 survivors and 35 nonsurvivors) which developped ARDS and other manifestations of MOF. We investigated the oxygen transport and also the hepatic blood flow (HBF) by means of excretion curve of indocyaningreen and circulating blood volume (I-135 HSA). HBF was dimished in 90% of nonsurvivors and 83% of survivors. As the norm is about 20 ml/min/kg in survivors we found 14.4±]4.9ml/min/kg and in nonsurvivors – 12.9±]4.9ml/min/kg, p<0.007. We found statisticaly significant correlations between his level and PaO₂, D(a-v)O₂, VA/Q and the utilization of the oxygen from tissues (p<0.01). These findings are in support of the understanding that liver has an important place in host defense homeostasis and it is essential to ameliorate hepatic support during ARDS with MOF in shock states.

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Citations should be made in the following way:
M. Tsareva, A. Christova, S. Todorova (Sofia, Bulgaria). Relationship between lung and hepatic function in MOF after traumatic shock. Eur Respir J 2001; 16: Suppl. 31, 1647

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