Source: International Congress 2016 – Pulmonary hypertension and pulmonary embolism: from the bench to the bedside
Disease area: Pulmonary vascular diseases

Abstract

Background and Aims: Acute pulmonary embolism (PE) is a fatal disease. Our aim in this study was to determine early and late all-cause mortality of acute PE patients and their clinical, laboratory, and imaging characteristics as potential mortality predictors.Methods: Adult patients diagnosed with acute PE in Hacettepe University Hospital between January 1, 2003 and June 30, 2013 and their all-cause mortality status were retrospectively analyzed. Parameters associated with increased mortality for each period were analyzed with age and sex controlled univariate and multivariate regression analyses.Results: Of 414 patients included, 192 were males. Mean age was 59.5±16.2 (min-max=18-93) years and median follow-up duration was 27 months. In early phase (£90 days after diagnosis), mortality rates for 30-day and 31- to 90-day were 13.3% and 9.6% respectively. Final models reached by multivariate regression analyses included advanced age, sex (female sex found as protector), history of heart failure, hypotension, mental status change, and decreased estimated glomerular filtration rate for 30-day mortality, but history of cancer, history of chronic lung disease, and hypoxemia for 31- to 90-day mortality. In terms of late mortality, 3-month to 1-year and 1- to 5-year mortality rates were 13.6% and 36.4% respectively. Only history of cancer and advanced age were found as related to increased mortality in univariate regression analyses for both periods, thus multivariate analysis wasn't performed.Conclusions: Determination of long-term risk of mortality could help management of acute PE patients. Despite few in number, present studies may guide planning future prospective studies.


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Abdulsamet Sandal (Ankara, Turkey), Abdulsamet Sandal, Elif Tugce Korkmaz, Funda Aksu, Deniz Köksal, Ziya Toros Selçuk, Ahmet Ugur Demir, Salih Emri, Lütfi Çöplü. Evaluation of predictors of early and late mortality in 414 acute pulmonary embolism patients. Eur Respir J 2016; 48: Suppl. 60, 2489

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