Source: International Congress 2016 – Pulmonary hypertension and pulmonary embolism: from the bench to the bedside
Disease area: Pulmonary vascular diseases

Abstract

Introduction: Bleeding is the most serious complication of anticoagulant therapy and its frequency ranges between 10-15%. Our objective was to assess the presence of acute bleeding complications [ABC] and during the follow-up [FBC] in a cohort of patients with PE.Methods: 373 PE admitted to our department were collected prospectively. ABC (until discharge) and FBC were recorded. We performed univariate and multivariate analysis (logistic regression) to assess what factors were related to ABC and FBC.Results: There were 11.5% ABC and 22.8% FBC. Multivariate analysis found that ABC were independently associated with : age (OR: 1; 95% CI: 1-1.06), male gender (OR 2.6; 95% CI: 1.2- 5.8 ), presence of syncope (OR: 2.1; 95% CI: 0.9-5), absence of dyspnea (OR:0.3, 95% CI: 0.1-0.7) and fibrinolytic therapy (OR: 5.3, 95% CI: 1.5-18.4). FBC were related to: age, presence of predisposing risk factors, severity involvement in CT angiography, presence of COPD, presence of non bleeding complications at follow-up, and length of treatment (> 12 months vs <12 months). In the multivariate analysis FBC were independently associated with: age (OR: 1; CI 95%: 1- 1.04), presence of predisposing risk factors (OR: 7.8; CI 95%: 1, 1- 52.5), severity involvement in CT angiography (OR: 8.7; CI 95%: 1.5-48.1), presence of non bleeding complications at follow up (OR: 3.1; CI 95%: 1, 7- 5.5) and length of treatment (OR: 6.5, CI 95%: 2.2-18.5).Conclusions: 1-In our experience ABC and FBC were common (11.5% and 22.8%, respectively). 2. ABC were associated with age, severity of the event and fibrinolytic therapy. 3. FBC seem to be related to underlying patient characteristics, intercurrent diseases and the length of therapy.


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Jacinto Hernandez Borge (Badajoz, Spain), Pedro Pires Goncalves, Jacinto Hernandez Borge, Maria del Carmen Garcia Garcia, Maria Jose Antona Rodriguez, Isabel Asschert Aguero, Amparo Sanz Cabrera, Miguel Benitez-Cano Gamonoso, Pilar Cordero Montero, Ignacio Rodriguez Blanco, Francisca Lourdes Marquez Perez. Hemorrhagic complications of treatment in patients with pulmonary embolism. Eur Respir J 2016; 48: Suppl. 60, 2488

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