Absorption, metabolism and excretion of fevipiprant (QAW039) investigated in vivo and in vitro

David Pearson (Basel, Switzerland), David Pearson, Yi Jin, Veit J. Erpenbeck, Ralph Woessner, Gian Camenisch, H. Markus Weiss

Source: International Congress 2016 – Pharmacological intervention in humans and murine models of asthma
Session: Pharmacological intervention in humans and murine models of asthma
Session type: Thematic Poster
Number: 1109
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
David Pearson (Basel, Switzerland), David Pearson, Yi Jin, Veit J. Erpenbeck, Ralph Woessner, Gian Camenisch, H. Markus Weiss. Absorption, metabolism and excretion of fevipiprant (QAW039) investigated in vivo and in vitro. Eur Respir J 2016; 48: Suppl. 60, 1109

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Absorption, distribution, metabolism, and elimination (ADME) of umeclidinium (UMEC) in healthy adults
Source: Annual Congress 2012 - The best of pharmacology treatments of airway diseases: new devices and drugs
Year: 2012

The uptake of ciclesonide-active metabolite and budesonide into human hepatocytes in vitro – the effect of serum protein binding
Source: Eur Respir J 2006; 28: Suppl. 50, 434s
Year: 2006

Pulmonary absorption rate and bioavailability of drugs in vivo in rats: Analysis of structure-absorption relationships
Source: Eur Respir J 2003; 22: Suppl. 45, 6s
Year: 2003

The absorption, distribution, metabolism and excretion (ADME) of single oral doses of AZD5069, a novel CXCR2 antagonist, in healthy male volunteers
Source: Annual Congress 2012 - The best of pharmacology treatments of airway diseases: new devices and drugs
Year: 2012

Modeling in vitro, ex vivo or in vivo?
Source: Research Seminar 2013 - Optimising models for human lung diseases and drug development
Year: 2013


Evidence of in vivo esterification of budesonide in humans
Source: Eur Respir J 2005; 26: Suppl. 49, 370s
Year: 2005

LSC 2012 abstract – Mitochondrial metabolism controls lung fibroblast activation in vitro and in vivo
Source: Annual Congress 2012 - Fibrogenesis between epithelial injury and fibroblast proliferation
Year: 2012

Deposition and metabolism of inhaled ciclesonide in the human lung
Source: Eur Respir J 2010; 36: 1113-1119
Year: 2010



Absorption behavior of riociguat (BAY 63-2521): Bioavailability, food effects, and dose-proportionality
Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Year: 2012


Tissue accumulation kinetics of ciclesonide-active metabolite and budesonide in mice
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD II
Year: 2008

Changes of enzymatic systems and different metabolites of lipogenesis under the conditions of experimental tuberculosis
Source: Annual Congress 2008 - Genetics, immunology and microbiology of tuberculosis
Year: 2008

Highly lipophilic fatty acid esters of the active metabolite of ciclesonide formed in vitro in rat lung tissue
Source: Eur Respir J 2004; 24: Suppl. 48, 345s
Year: 2004

Different tissue accumulation kinetics of ciclesonide-active metabolite and budesonide in mice
Source: Eur Respir J 2006; 28: Suppl. 50, 433s
Year: 2006

Glutathione synthesis in rat lungs: effect of growth and maturation
Source: Eur Respir J 2003; 22: Suppl. 45, 73s
Year: 2003

Effects of pendrin inhibitor (PDI_C01) in vitro, and in vivo models of lipopolysaccharide-induced airway inflammation.
Source: International Congress 2019 – Biomarkers, laboratory findings and pre-clinical data in acute respiratory failure
Year: 2019


Acute effects of cisplatin on mucociliary function: In vitro measurements
Source: Annual Congress 2010 - Pathology of lung cancer
Year: 2010


Uptake, retention and metabolism of ciclesonide in human alveolar epithelial cells
Source: Eur Respir J 2005; 26: Suppl. 49, 255s
Year: 2005

Experimental emphysema: influence of tocopherol on serum iron content and lipid profile
Source: Eur Respir J 2007; 30: Suppl. 51, 142s
Year: 2007

Pharmacokinetics and pre-clinical efficacy of ralinepag (APD811) in humans and rats
Source: International Congress 2017 – New perspectives from experimental models of pulmonary hypertension
Year: 2017




Corticosteroid lipophilicity is a more important determinant of corticosteroid uptake into human hepatocytes than serum protein binding
Source: Eur Respir J 2007; 30: Suppl. 51, 351s
Year: 2007