Source: International Congress 2016 – Monitoring airway diseases with clinical tools
Disease area: Airway diseases

Abstract

Background Numerous markers of asthma severity and activity are available. Among them, functional parameters, clinical assessment and biomarkers of inflammation are the most widely used. It is difficult to establish a clear correlation among theses parameters, as each of them measure a particular aspect of the disease.ObjectiveThe aim of the study was to clarify the correlation between Asthma Control Test (ACT) scores, exhaled nitric oxide (eNO) levels and forced expiratory volume at 1s (FEV1).MethodsIt was a cross sectional study including patients treated for asthma for at least 3 months. All patients completed the ACT questionnaire and underwent testing for eNO and spirometry.ResultsA total of 148 asthmatic patients were included. The mean age was 44.2 ±14.7 years and 55.4% of patients were female. The ACT scores varied from 5 to 25 (median 22), and asthma control was obtained in 71.7% of patients. The percentage of predicted FEV1 ranged from 42% to 121% (mean 86%) and eNO varied between 10 and 175 ppb (mean 30.4 ppb). ENO values in the controlled group were significantly better than in uncontrolled group (27 ppb vs 42.1, p=0.01). The ACT score was negatively correlated with eNO values (r=-0.33, p=0,001) and positively correlated with percentage of predicted FEV1 (r=0.1, p= 0.08). However, the association was weak in view of each correlation coefficient value. There was no correlation between FEV1 and eNO ( r=0.06, p=0.4).Conclusion:ACT, FEV1 and eNO quantify variables that evaluate asthma in different ways and they are complementary. Thus, ACT should be used in combination with pulmonary function tests and/or eNO measurements.


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Ferdaous Yangui (Tunis, Tunisia), Ferdaous Yangui, Rimeh Ayari, Mariem Triki, Maher Abouda, Hend Khouani, Mohamed Ridha Charfi. Correlation between Arabic version of the asthma control test, forced expiratory volume at 1 s and exhaled nitric oxide in Tunisian asthmatic patients. Eur Respir J 2016; 48: Suppl. 60, 1054

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