Source: International Congress 2016 – Monitoring airway diseases with clinical tools
Disease area: Airway diseases

Abstract

Background and AimData about patients with asthma frequently derived from randomized-controlled trials that, however, do not represent the real life. We have evaluated the control of asthma in a population referred to a third-level clinic, in a follow-up of 5 years; this part of the study considers the baseline evaluation.MethodsAnthropometric characteristics, smoking status, occupational risk, presence of atopy, rhinosinusitis (RS) and gastroesophageal reflux disease (GERD), bronchial inflammation (FeNO), airway hyperreactivity (AH), questionnaires (ACT) were recorded. Accordingly, we divided patients as Controlled (C), Partially Controlled (PC) and Not Controlled (NC).Results750 patients (62% males; mean age 44 y; mean FEV₁ 93% of pred.) were enrolled. 41% had a family history of asthma with an occupational risk identified in 34%. 16% were current smokers, while 27% were former smokers. 42% reported dyspnea, 29% and 24% diurnal and nocturnal symptoms, respectively. Symptoms/signs compatible with RS and GERD were present in 15% and 22%, respectively. The AH was defined as severe (14%), moderate (45%), and mild (41%). The median FeNO and ACT scores were 24 and 22, respectively. Finally, patients were PC (59%), NC (24%), and C (17%). In a multivariate logistic model, the presence of RS increases the risk of having PC/NC patients (OR 2.09, 95% IC 1.25 to 3.49, p=0.005).ConclusionOur study in real life in a cohort of outpatients asthmatics shows: a) the low prevalence of patients with a complete disease control; b) the high prevalence of patients with a smoking habit; c) the co-existence of important comorbidities such as rhinosinusitis and GERD. Rhinosinusitis can increase the poor control of asthma.


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Ernesto Crisafulli (Pavullo, Italy), Ernesto Crisafulli, Roberta Pisi, Fabio Arpinelli, Marina Aiello, Meryem El Majdoub, Davide Feci, Antonella Ielpo, Massimo Guerriero, Giuseppina Bertorelli, Alfredo Chetta. The control of asthma in real life: Baseline evaluation of a long-term study. Eur Respir J 2016; 48: Suppl. 60, 1053

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