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London 2016
Sunday, 04.09.2016
Monitoring airway diseases with clinical tools
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COPD related fatigue (COPD-RF) as a patient centred outcome tool in COPD: Various predictors and its correlation with other outcome parameters
Sheetal Chaurasia (Bangalore, India), Sheetal Chaurasia, Alamelu Haran, Anish Reddy, Pavny Chawla
Source:
International Congress 2016 – Monitoring airway diseases with clinical tools
Session:
Monitoring airway diseases with clinical tools
Session type:
Thematic Poster
Number:
1046
Disease area:
Airway diseases
Abstract
Introduction:Over the years approach to COPD has changed. The focus of evaluation is shifting from physiological outcome parameters to patient centred outcomes. COPD-RF is one such patient related outcome that is of considerable importance to the patients as fatigue is the second common distressing symptom in COPD & is a major concern for the patients.Aims:We aim to identify the predictors of COPD-RF and its correlation with other outcome tools like FEV1, 6 minute walk distance(6MWD),MMRC grade, BODE index & inflammatory markers. Methodology: 50 stable COPD patients were taken in the study. MMRC grade, FEV1, 6MWD, BODE index, CRP level and sputum neutrophil% obtained. COPD-RF was assessed using 13 item (FACIT-fatigue) questionnaire. The correlation analysis was done by spearman rank correlation and ANOVA. Predictors of COPD-RF were identified by multiple linear regression.RESULT: The fatigue score showed significant correlation with inflammatory markers (CRP-r=-0.675; neutrophil%- r=-0.485) & 6MWD(r=-.428). Categorical variables (MMRC, FEV1 GOLD stages & BODE quartiles) also showed significant difference of fatigue among categories. BODE index & serum CRP were identified as the statistically significant predictors of fatigue, suggesting COPD-RF could be a reflection of severity of underlying pathophysiologic process ie systemic inflammation.Conclusion: BODE index and CRP levels are the two important surrogate markers that predicts COPR-RF implying a role of systemic inflammation in the pathogenesis of fatigue & COPD-RF could be an indicator of longterm prognosis of the disease & should be routinely evaluated during COPD assessment.
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Sheetal Chaurasia (Bangalore, India), Sheetal Chaurasia, Alamelu Haran, Anish Reddy, Pavny Chawla. COPD related fatigue (COPD-RF) as a patient centred outcome tool in COPD: Various predictors and its correlation with other outcome parameters. Eur Respir J 2016; 48: Suppl. 60, 1046
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