Comparison of patient-reported outcomes (PROs) during acute exacerbation of chronic obstructive pulmonary disease Saya Nakamura (Toyokawa-shi, Japan), Saya Nakamura, Masaaki Kusunose, Kazuyoshi Senda, Koichi Nishimura
Source: International Congress 2016 – Monitoring airway diseases with clinical tools
Session: Monitoring airway diseases with clinical tools Session type: Thematic PosterNumber: 1043
Disease area: Airway diseasesAbstract BACKGROUND: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is defined by change of the symptoms. The establishment of a standardized method to quantify and evaluate the symptoms is expected. STUDY OBJECTIVE: We investigated and compared the responsiveness of the Exacerbations of Chronic Pulmonary Disease Tool (EXACT), the COPD Assessment Test (CAT), the St. George's Respiratory Questionnaire (SGRQ), Dyspnea-12 and Hyland Scale (global scale) during the recovery phase from AECOPD. METHOD: We followed 28 patients who had been hospitalized because of AECOPD, and compared the scores of each PROs at the baseline with the scores obtained 14, 28, 56 and 84 days later. RESULTS: The EXACT total score (possible range; 0-100) improved from 50±12 to 32±14, CAT score (possible range; 0-40) from 24±9 to 13±8, the SGRQ score from 55±21 to 41±24, Dyspnea-12 score (possible range; 0-36) from 10±10 to 5±6, and Hyland Scale (possible range; 0-100) from 45±19 to 62±21 during the first 28 days. The effective size of the EXACT total and CAT score was -1.36 and -1.30 respectively, although the SGRQ, Dyspnea-12, and Hyland Scale were less responsive with the effect size of -0.52, -0.64, and 0.82. Therefore, the EXACT total score and CAT score showed best responsiveness. From the perspective of score distribution, only the EXACT total score showed normal distribution. CONCLUSION: The EXACT total score may be the ideal measure during the recovery phase from AECOPD.Rating:
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Saya Nakamura (Toyokawa-shi, Japan), Saya Nakamura, Masaaki Kusunose, Kazuyoshi Senda, Koichi Nishimura. Comparison of patient-reported outcomes (PROs) during acute exacerbation of chronic obstructive pulmonary disease. Eur Respir J 2016; 48: Suppl. 60, 1043
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