Source: International Congress 2016 – Non-inflammatory assessment of airway disorders
Disease area: Airway diseases

Abstract

CT densitometry is the most accurate, specific and sensitive measure of the severity of emphysema in patients with COPD and a₁-antitrypsin deficiency (AATD). Health status is increasingly documented using subjective measurement tools such as SGRQ (St Georges Respiratory Questionnaire) and the CAT (COPD Assessment Test) score which relates (though poorly) to the degree of physiological impairment (Ghobadi et al., 2012). The relationship of these health status tools to objective measures of the degree of emphysema determined by CT scanning parameters is unknown.The relationship between SGRQ and CAT scores with CT scan densitometry was explored in the first 84 patients with PiZZ AATD analysed as part of the NIHR Rare Diseases Translational Research Collaboration. CT density was measured as the percent of low attenuation voxels (LAA) at -950 HU, and the 15^th percentile point using semi-automated software programme, Pulmo-CMS (Medis Medical Imaging, Leiden, Netherlands) and questionnaires were completed as part of broad clinical assessment.The patients were aged 31-65 and had an FEV1(% predicted) that ranged from 15-125. As expected the health status also showed a wide range from 6-88 for the SGRQ and 1-39 for the CAT. There was a significant negative correlation between SGRQ and both the %LAA value at -950HU and perc15 (r=-0.390, p<0.001, and r=0.332, p<0.001 respectively) and CAT scores (r=0.262, p<0.006 and r=-0.323 p=0.001 respectively).These results demonstrate that the degree of emphysema in AATD, as quantified by CT density measurements, is related to conventional measures of health status.


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Diana Crossley (Birmingham, United Kingdom), Diana Crossley, Ross Edgar, Rob Stockley. The NIHR translational research collaboration: The relationship between CT densitometry and quality of life in alpha one antitrypsin deficiency. Eur Respir J 2016; 48: Suppl. 60, 1028

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