Source: International Congress 2016 – Non-inflammatory assessment of airway disorders
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Objectives:In Cystic fibrosis (CF) and Primary ciliary dyskinesia (PCD) medical history of cough is important to identify disease progress, infective exacerbations and response to therapy. Thus treatment decisions are based on highly subjective patient´s reports what emphasises the need for objective cough monitoring.Methods:We investigated 28 healthy subjects (age 22.5 years (12; 43); median (min; max)), 21 patients with CF (26 (10; 44)) and 17 PCD patients (21 (9; 43)) at the University children´s hospital Muenster, Germany. In all patients cough-sounds were recorded and analysed with LEOSound-Monitor® (Heinen und Löwenstein, Bad Ems, Germany) during sleep. Kruskal-Wallis, Mann Whitney U test and Spearman´s correlation were applied.Results:The median (min; max) recorded time for healthy subjects, CF and PCD was 6.58 hours (5.42; 8.28), 7:58 (6:02; 9:46) and 7:51 (5:50; 9:34), respectively; cough counts per hour (cough/h median (min; max)) was 0 (0.0; 1.14), 2.15 (0.0; 62.6) and 0.37 (0.00; 7.75), respectively. Cough/h was statistically different between healthy subjects and CF (p<0.001) and between healthy subjects and PCD (p<0.01). CF patients tended to cough more than PCD patients (p=0.14). In CF cough/h correlates with FEV1%pred (p<0.001; rho=-0.81) and Immunoglobulin G (p=0.004; rho=0.65), in PCD cough/h correlates with FEV1%pred (p=0.02; rho=-0.64) and FVC%pred (p=0.03; rho=-0.60).Conclusions:Cough detection with LEOSound-Monitor® is feasible in CF, PCD and healthy subjects. CF and PCD patients cough significantly more than healthy subjects. Cough in CF and PCD correlates with parameters of disease severity, which indicates the usefulness of cough monitoring in CF and PCD.


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Joerg Grosse-Onnebrink (Muenster, Germany), Joerg Grosse-Onnebrink, Andrea Radine, Claudius Werner, Heymut Omran. Cough detection in cystic fibrosis, primary ciliary dyskinesia and health. Eur Respir J 2016; 48: Suppl. 60, 1024

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