Source: International Congress 2016 – Non-inflammatory assessment of airway disorders
Disease area: Airway diseases

Abstract

Introduction-Current GINA guidelines recommend control based management. Subjective assessment of symptom control may lack in estimating disease severity and functional ability.Aims–To correlate Asthma control with lung volumes, airway resistance, conductance ,diffusion capacity (DLCO) and 6 minute walk test (6MWT).Methods - 64(18 females & 46 males) Asthmatic patients, stratified according to GINA asthma control, underwent spirometry, body plethysmography, DLCO and 6MWT. Comparison was done using ANOVA and Chi Square tests.Results -Indices of hyperinflation ie. FRC%,RV%,RV/TLC% (not TLC%) as well as airway resistance(Raw) were significantly increased while FEV1%, specific airway conductance(sGaw) along with 6 minute walk distance(6MWD) were significantly decreased with worsening of Asthma control.

Table 1

Parameters	well controlled (mean±sd)	partially controlled (mean±sd)	uncontrolled (mean±sd)	P value
FEV1%	72.68±12.50	50.00±18.78	50.81±22.22	<0.001
FRC%	108.32±21.05	172.38±62.65	182.31±76.13	<0.001
TLC%	96.63±11.71	111.54±21.56	110.31±32.37	0.14
RV%	124.16±26.18	195.31±60.72	217.25±93.24	<0.001
RV/TLC%	133.21±21.38	173.31±31.11	193.63±57.51	<0.001
Raw%	142.68±73.50	303.08±185.49	401.94±200.06	<0.001
sGaw%	93.58±46.39	45.77±30.04	36.97±28.53	<0.001
DLCO%	96.42±13.98	80.69±9.84	87.81±15.69	0.21
6MWD (m)	436.84±30.52	374.23±66.25	331.03±57.65	<0.001

 

Uncontrolled Asthmatics had longer duration of illness (p=0.029) and greater BMI (p=0.04) as compared to controlled one's.Conclusion-Lung volumes ,airway resistance & conductance along with 6MWT may supplement GINA level of Asthma control in assessing patient's underlying physiological as well functional status over time.


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Isha Garg (Jodhpur, India), Isha Garg, K.C. Agarwal, Gopal Purohit, C.R. Choudhary, Naveen Dutt, Sunil Vyas, Srikant Agarwal, U. Narendra. Correlation of GINA asthma control with lung volumes, airway resistance, diffusion and 6MWT. Eur Respir J 2016; 48: Suppl. 60, 1022

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