Source: International Congress 2016 – Asthma: mechanisms and biomarkers that promote clinical understanding
Disease area: Airway diseases

Abstract

The clinical value of eosinophils (Eo) in asthma has been shown, but asthma and obesity association remains unclear. Aim was to analyse the impact of normalising of body mass index (BMI) in obese asthma patients on sputum and blood Eo count and asthma control.140 obese patients (age:49.94±1.68 years; M/F ratio:0.82, BMI:30.3±0.3) with partially controlled asthma and eosinophilia in sputum and blood were included. Patients were divided in IgE high (³100 IU/ml) and IgE low (<100 IU/ml). 113 patients were on restrictive diet of which 80 (n=40 for both: IgE high and IgE low) normalised BMI (<25). 60 obese patients (n=30 for both: IgE high and IgE low), without diet, were controls. All patients were treated with moderate dose of inhaled corticosteroids (IGK) with no changes in dose during 3 months of study duration.Before diet, BMI, sputum and blood Eo, predicted forced expiratory volume in first second (FEV1%), Asthma Control Test (ACT) and Asthma Quality of Life Questionnaire(AQLQ) were similar between IgE high and IgE low patients. Sputum Eo count decreased only in IgE low patients (before vs. after diet: 6.8±1.7 vs. 1.2±0.3; p<0.001), after diet. After study, blood Eo count was similar in all patients, as well as sputum Eo count in controls. FEV1%, ACT and AQLQ improved in both IgE high and IgE low patients, but IgE low patients showed more benefit, after diet (IgE low vs. high: FEV1%: 81.9±0.5 vs. 78.9±0.5; p<0.0001; ACT >19: 42% vs. 11%; p<0.01; AQLQ: 4.7±1.3 vs. 2.3±0.4; p<0.01).Decreasing of BMI in obese patients with partially controlled asthma improves response to IGK resulting in improved lung function, asthma control and quality of life, particularly in IgE low patients.


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Edin Jusufovic (Tuzla, Bosnia and Herzegovina), Edin Jusufovic, Mitja Kosnik, Rifat Sejdinovic, Elida Turkusic, Munevera Osmic, Alma Nadarevic, Fransi Petrak, Dzenan Halilovic, Azra Jusufovic, Besim Prnjavorac. Obese patients with partially controlled asthma: Weight control shows more benefit in IgE low patients. Eur Respir J 2016; 48: Suppl. 60, 574

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